OBJECTIVES Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous and persistent environmental pollutants and food contaminants. Both are neurotoxic, especially for the developing nervous system. MATERIAL AND METHODS Female rats were exposed from day 7 of pregnancy up to day 21 after the delivery to MeHg in drinking water, PCB 153 per os or MeHg+PCB 153. Assessment of the ex...

Previous reports have suggested delayed dental development in Down's syndrome (mongolism), but without quantification and without exclusion of subjects with cretinism, with a normal chromosomal complement, or with translocations and mosaics of various sorts. Accordingly, the tooth formation of 25 subjects with Down's syndrome, verified as trisomy G by karyotyping and excluding subjects with cre...

Polymorphic light eruption (PLE) is a photodermatosis (i.e. "sun allergy") with a high prevalence, particularly among young women in temperate climates. It is characterized through itchy skin lesions of variable morphology, occurring in spring or early summer on sun exposed body sites. As yet the exact etiology and pathogenesis of PLE are unknown although a resistance to ultraviolet (UV)-radiat...

SD: Shiitake dermatitis SM: Shiitake mushroom INTRODUCTION Lentinula edodes, or shiitake mushroom (SM), is typically grown in EasternAsia and used in traditional Asian medicine and cuisine. Recently, SM became popular in Western culture and is now the second most commonly consumed mushroom in the world. Although rare, adverse reactions to SM have been previously reported. In mushroom farm worke...

A very short, microcephalic, and mentally retarded 2 year old girl showed minor anomalies including prominent occiput, delayed closure of the anterior fontanelle, high frontal hairline, prominent ears, upward slanting palpebral fissures, a small nose with bulbous tip, delayed tooth eruption and bone maturation, and short and tapering fingers and toes. She did not have a white forelock. Cytogene...

objective : tooth eruption has been a subject of extensive scientific studies; and literature is replete with different mechanisms of migration of a tooth from its bony crypt into the oral cavity. however, there is no common ground on the nature and source of the propelling force among the proponents of these theories. the purpose of this study was to explore the possibility of unifying the cur...

Fixed drug eruption is an uncommon adverse drug reaction caused by delayed cell-mediated hypersensitivity. Levocetirizine is an active (R)-enatiomer of cetirizine and there have been a few reports of fixed drug eruption related to these antihistamines. We experienced a case of levocetirizine-induced fixed drug eruption and cross-reaction with other piperazine derivatives confirmed by patch test...

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a cutaneous drug reaction characterized by erythema over the buttocks, thighs, groin, and flexural regions most commonly associated with the use of beta-lactam antibiotics. Although the exact pathophysiology of this disease remains unknown, it is theorized to be the result of a delayed hypersensitivity response presentin...