6-mercaptopurine (6-MP) ~ has been shown to suppress the expression of certain experimental and clinical immune responses. These include delayed cutaneous reactivity to antigen (1), allograft rejection (2), manifestations of certain "autoimmune" disorders (3), and some types of humoral antibody response (4). The mechanisms involved in these suppressive effects of 6-MP are still open to question...

BACKGROUND Corticosteroids (CS) are widely used in the treatment of asthma, allergic disorders and other immunological diseases due to their anti-inflammatory and immunosuppressive properties. Physicians seldom suspect them of causing allergic reactions. However, more and more cases of hypersensitivity reactions to CS have been described. Reports of delayed allergic reactions to CS in patients ...

Inoculation of P815 tumor cells into the anterior chamber of eyes of BALB/c mice produces Anterior Chamber Associated Immune Deviation (ACAID) whereby delayed hypersensitivity responses to the minor H antigens of the tumor cells are suppressed. In our laboratory, impaired delayed hypersensitivity is obtained in the majority, but not all normal BALB/c recipients. In the minority, typcial delayed...

Neonatal guinea pigs during the first 2 weeks of life did not indicate the presence of delayed hypersensitivity intradermally, after sensitization with purified soluble antigens in dose levels that induced detectable delayed hypersensitivity in the skin of adults. Although Arthus type allergy was detectable in newborns, circulating antibody frequently preceded its appearance by several days. Pa...

PURPOSE To determine whether cultured retinal pigment epithelial (RPE) cells implanted in the subconjunctival space induce an immune response against autoantigens and whether an active downregulation is achieved by RPE grafts placed in the anterior chamber and within the subretinal space. METHODS Cultured RPE cells from eyes of newborn C57BL/6 mice were implanted in the subconjunctival space,...

Epstein-Barr virus and cytomegalovirus antibody levels were not higher in patients with rheumatoid arthritis compared to matched controls. Delayed hypersensitivity, measured by skin test reactivity, was depressed in rheumatoid arthritis. There was no correlation between virus antibody titres and delayed hypersensitivity.

Delayed hypersensitivity reaction in mice was commonly enhanced with various anti-cancer agents administered as single or intermittent high doses but not consecutive divided doses. The effect of anti-cancer agents on the delayed hypersensitivity reaction was thought to be due to elimination of suppressor T cell activity.

The effects of the following parameters on the immunologic specificity of delayed and immediate hypersensitivity reactions were investigated in the guinea pig using the picryl and p-toluenesulfonyl systems: (a) the contribution of the carrier protein, (b) the effect of the number of hapten groups per molecule of the immunizing and challenging antigens, and (c) the effect of interposing a 6 carb...