نتایج جستجو برای: dendritic spine density

تعداد نتایج: 505589  

Journal: :Neuron glia biology 2010
Jocelyn J Lippman Bell Tamar Lordkipanidze Natalie Cobb Anna Dunaevsky

In the cerebellum, lamellar Bergmann glial (BG) appendages wrap tightly around almost every Purkinje cell dendritic spine. The function of this glial ensheathment of spines is not entirely understood. The development of ensheathment begins near the onset of synaptogenesis, when motility of both BG processes and dendritic spines are high. By the end of the synaptogenic period, ensheathment is co...

Journal: :Cerebral cortex 2010
Rebecca M Shansky Carine Hamo Patrick R Hof Wendy Lou Bruce S McEwen John H Morrison

We have recently reported in male rats that medial prefrontal cortex (mPFC) neurons that project to the basolateral nucleus of the amygdala (BLA) are resilient to stress-induced dendritic remodeling. The present study investigated whether this also occurs in female rats. This pathway was identified using the retrograde tracer Fast Blue injected into the BLA of ovariectomized female rats with es...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Martin Fuhrmann Gerda Mitteregger Hans Kretzschmar Jochen Herms

Spine loss represents a common hallmark of neurodegenerative diseases. However, little is known about the underlying mechanisms, especially the relationship between spine elimination and neuritic destruction. We imaged cortical dendrites throughout a neurodegenerative disease using scrapie in mice as a model. Two-photon in vivo imaging over 2 months revealed a linear decrease of spine density. ...

2015
Rasha Refaat Mahmmoud Sunetra Sase Yogesh D. Aher Ajinkya Sase Marion Gröger Maher Mokhtar Harald Höger Gert Lubec Georges Chapouthier

BACKGROUND Changes in synaptic structure and efficacy including dendritic spine number and morphology have been shown to underlie neuronal activity and size. Moreover, the shapes of individual dendritic spines were proposed to correlate with their capacity for structural change. Spine numbers and morphology were reported to parallel memory formation in the rat using a water maze but, so far, th...

2016
George S Vidal Maja Djurisic Kiana Brown Richard W Sapp Carla J Shatz

Synapse density on cortical pyramidal neurons is modulated by experience. This process is highest during developmental critical periods, when mechanisms of synaptic plasticity are fully engaged. In mouse visual cortex, the critical period for ocular dominance (OD) plasticity coincides with the developmental pruning of synapses. At this time, mice lacking paired Ig-like receptor B (PirB) have ex...

Journal: :Hippocampus 2007
Alexis M Stranahan David Khalil Elizabeth Gould

Physical activity enhances hippocampal function but its effects on neuronal structure remain relatively unexplored outside of the dentate gyrus. Using Golgi impregnation and the lipophilic tracer DiI, we show that long-term voluntary running increases the density of dendritic spines in the entorhinal cortex and hippocampus of adult rats. Exercise was associated with increased dendritic spine de...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Seungnam Han Jungyong Nam Yan Li Seho Kim Suk-Hee Cho Yi Sul Cho So-Yeon Choi Jeonghoon Choi Kihoon Han Youngrim Kim Moonseok Na Hyun Kim Yong Chul Bae Se-Young Choi Eunjoon Kim

PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TAN...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
T J Shors C Chua J Falduto

Dendritic spines are postsynaptic sites of excitatory input in the mammalian nervous system. Despite much information about their structure, their functional significance remains unknown. It has been reported that females in proestrus, when estrogen levels are elevated, have a greater density of apical dendritic spines on pyramidal neurons in area CA1 of the hippocampus than females in other st...

Journal: :The Journal of comparative neurology 2010
Paul M Forlano Catherine S Woolley

The nucleus accumbens (NAc) plays a central role in motivation and reward. While there is ample evidence for sex differences in addiction-related behaviors, little is known about the neuroanatomical substrates that underlie these sexual dimorphisms. We investigated sex differences in synaptic connectivity of the NAc by evaluating pre- and postsynaptic measures in gonadally intact male and proes...

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