Dentinogenesis is a necessary prerequisite for dental tissue engineering. One of the steps for dentinogenesis is to obtain large quantities of highly purified odontoblasts. Therefore, we have undertaken an experiment applying different concentrations of β-glycerophosphate (β-GP) to induce the differentiation of dental pulp stem cells (DPSCs) in a long-term 28-day culture. In the meanwhile, we h...

Dentinogenesis imperfecta (DI) is a hereditary condition that may affect both primary and permanent dentition and is characterized by abnormal dentin formation. The teeth may be discolored with chipping of enamel and, in untreated cases, the entire dentition may wear off to the gingiva. This may lead to the formation of abscesses, tooth mobility, and early loss of teeth. In the Indian populatio...

Hereditary defects of dentin include dentinogenesis imperfecta (DGI) and dentin dysplasia (DD). They are characterized by abnormal dentin for­ mation. Within the last 32 years, since the first classification system was pro­ posed, significant advances have been made regarding their genetic aetio­ logies. In the classification system suggested by Shields et al (1973), den­ tinogenesis imperfecta...

We consider Smoluchowski’s equation with a homogeneous kernel of the form a(x, y) = xy + xy with −1 < α ≤ β < 1 and λ := α + β ∈ (−1, 1). We first show that self-similar solutions of this equation are infinitely differentiable and prove sharp results on the behavior of self-similar profiles at y = 0 in the case α < 0. We also give some partial uniqueness results for self-similar profiles: in th...

The odontoblastic differentiation of dental pulp stem cells (DPSCs) associated with caries injury happens in an inflammatory context. We recently demonstrated that there is a link between inflammation and tissue regeneration, identified via enhanced DPSC-mediated dentinogenesis vitro. Brain-derived neurotrophic factor (BDNF) nerve growth factor-related gene family molecule which functions throu...

Inherited dentin defects are classified into three types of dentinogenesis imperfecta (DGI) and two types of dentin dysplasia (DD). The genetic etiology of DD-I is unknown. Defects in dentin sialophosphoprotein (DSPP) cause DD type II and DGI types II and III. DGI type I is the oral manifestation of osteogenesis imperfecta (OI), a systemic disease typically caused by defects in COL1A1 or COL1A2...

This paper aims to review the biological and physicochemical properties of mineral trioxide aggregate (MTA) with respect to its ability to induce reparative dentinogenesis, which involves complex cellular and molecular events leading to hard-tissue repair by newly differentiated odontoblast-like cells. Compared with that of calcium hydroxide-based materials, MTA is more efficient at inducing re...

Dentine dysplasia type II is an autosomal dominant disorder in which mineralization of the dentine of the primary teeth is abnormal. On the basis of the phenotypic overlap between, and shared chromosomal location with, dentinogenesis imperfecta type II, a second disorder of dentine mineralization, it has been proposed that the two conditions are allelic. As recent studies have shown that dentin...