Background: New evidence suggests an important role for spinal glial cells in development of opioid dependence. Curcumin, a component of the Curcuma Longa, has shown to act as a suppressor of microglial cells. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on spinal microglial cells and inflammatory cytokines. Methods: In...

objective: the anxiety profile in the stimulant-sensitized animals is not clear. thus, this study was conducted to elucidate the effects of acute and chronic administration of methamphetamine (meth) on the anxiety profile. the aim of this study was to examine whether meth-sensitized rats would show an increase in the expression of anxiogenic-like behaviors and to determine whether a low dose of...

Background: According to recent researches, decision-making style and personality traits play an important role in the drug dependence vulnerability. The aim of current research was to investigate the moderator role of decision-making styles on relationship between personality and drug dependence vulnerability. Materials and Methods: Two hundred and twenty students of Tehran Payame Noor Univer...

advances in understanding the neurobiology of addiction to stimulants, has made it possible for researchers to identify medicines effective in initiation of treatment and prevention of stimulants relapse, based on pharmacological effects of various medicine. some of these medicine and vaccines have brought promising results in clinical trials on cocaine dependent patients. studies regarding met...

introduction: nicotine is the psychoactive substance responsible for establishing and maintaining smoking dependence. cyp2a6 is the primary enzyme that inactivates nicotine to cotinine .genetic variation in cyp2a6 accounts for some of the inter-individual variability in nicotine metabolism and has been indicated to influence smoking behavior and dependence. therefore, the aim of this study was ...

Background: New evidence suggests an important role for spinal glial cells in development of opioid dependence. Curcumin, a component of the Curcuma Longa, has shown to act as a suppressor of microglial cells. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on spinal microglial cells and inflammatory cytokines. Methods: In...

  Tolerance and dependence are two main problems that have limited morphine administration as an analgesic drug and they might be as a result of changes in the number and affinity of receptors, dysfunction of adenylate cyclase, impaired coupling between activated µ receptor and K+ channels, and changes in the K+ and Ca2+ channels. There are several reports concerning the role of some of these...

introduction:adenosine as a potent vasodilator has physiological role in regulation of regional cerebral blood flow (rcbf). metod: laser-dِoppler flowmetry technique was used to study pial vessels blood flow responses to adenosine receptors agonists and antagonist. male sprague dawley rats (250-350g) that were housed in standard conditions, were anesthetized with urethane (1.5g/kg). adenosine (g...