Most studies aimed at understanding the link between inflammation and cancer progression have focused on macrophages. In a recent study published in PLoS Biology, Toh B et al (2011) Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumorPLoS Biol9 e1001162, we show that a subset of granulocytic cells already known to ...

In this issue of Clinical Cancer Research, Zoglmeier and colleagues show that CpG, via the induction of IFN-α, matures myeloid-derived suppressor cells to abrogate immune suppression in 2 murine solid tumor models.

Patients with programmed death-ligand 1 positive (PD-L1+), locally advanced or metastatic, non-squamous non-small cell lung cancer (NSCLC) have a poor prognosis and treatment options are limited. Sitravatinib, selective tyrosine kinase inhibitor, reduces the number of myeloid-derived suppressor cells regulatory T cells, promotes expansion migration antitumor cytotoxic increases ratio M1/M2-pola...

Antigen-specific, T cell-derived factors have been the subject of extensive studies as possible mediators of immunoregulatory interactions (reviewed in references 1-3). Functionally, two kinds of factor, helper and suppressor, can be distinguished. The suppressor factors (TsF), x again, fall into two categories, namely, inducer factors (TsiF) that play a role in communication between T cell set...

Abstract Despite the remarkable outcome of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC), a large number patients remain unresponsive to this therapy. A key factor unresponsiveness ICIs is intrinsic therapeutic resistance where monocytic myeloid-derived suppressor cells (M-MDSCs) contribute significantly via suppressing CD8 +T mediated anti-tumor response. Our result...

Over the past decade there have been numerous descriptions of suppressor T cells (Ts) and of factors derived from such cells. Several apparently related, but nonidentical, suppressor regulatory pathways consisting of a variety of T-T interactions have been described (1-4). Our laboratory has concentrated on one of these models of antigen-specific suppression involving the hapten 4-hydroxy3-nitr...

Although tissue-derived high mobility group box 1 (HMGB1) is involved in many aspects of inflammation and tissue injury after trauma, its role in trauma-induced immune suppression remains elusive. Using an established mouse model of peripheral tissue trauma, which includes soft tissue and fracture components, we report here that treatment with anti-HMGB1 monoclonal antibody ameliorated the trau...