The biological role of dehydroepiandrosterone (DHEA) and its less active sulphated conjugate DHEAS was investigated in two experiments using Yucatan miniature swine. In experiment 1, plasma levels of both DHEA(S) among males were greater than female pigs that ranged in age from 0.3 to 84 mo old (P < 0.0001). In males, DHEA(S) were related inversely to serum triglycerides; DHEA was positively re...

We investigated the mechanism of dissociation of cortisol and dehydroepiandrosterone sulfate (DHEA-S) secretion by the adrenal glands after the removal of an adrenal gland containing an adrenocortical adenoma in a patient with Cushing's syndrome. After removal of the adrenocortical adenoma, the serum cortisol rapidly decreased from 24.6 +/- 6.4 micrograms/dl (mean +/- SD, n = 6) to 0.7 +/- 0.5 ...

UNLABELLED To present a review of cross-sectional and longitudinal studies that investigate the relationship between the hormones Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone sulfate (DHEA-S) and cognition. METHODS The cognition items included in this review were global cognitive function, memory, attention, executive function, intelligence, perception and visuospatial ability. A ...

OBJECTIVE To evaluate the effects of a low-dose DHEA supplementation on hormonal parameters in early and late postmenopausal women. DESIGN Prospective case study. SETTING Postmenopausal women in a clinical research environment. PATIENT(S) Twenty postmenopausal women were divided in two groups according to age (50-55 and 60-65 years). INTERVENTION(S) All patients underwent hormonal evalu...

Objective The pathophysiology of major depressive disorder (MDD) is still not well understood. Conflicting results for surrogate. biomarkers in MDD have been reported, which might be a consequence of the heterogeneity of MDD patients. Therefore, we aim to investigate how the severity of depression and various symptom domains are related to the levels of dehydroepiandrosterone sulfate (DHEA-s) i...

BACKGROUND Previous studies suggested that alterations in serum cortisol and DHEA-S levels may play a role in the pathophysiology of schizophrenia. AIM To compare serum cortisol and DHEA-S levels between patients with schizophrenia and healthy controls and to evaluate their association with the response to antipsychotic treatment. MATERIAL AND METHODS In this clinical prospective study were...

BACKGROUND Although a growing body of evidence indicates that androgens modulate immune response and certain alterations in sex hormone metabolism and balance are thought to predispose an individual to immune-mediated diseases, few studies have investigated the role of androgens in atopic eczema/dermatitis syndrome (AEDS). OBJECTIVE We evaluated serum concentration of dehydroepiandrosterone s...

Early observations have shown that preventive educational efforts towards experience of stress entail advantages in terms of improved well-being, health and performance. We examined the influence in healthy subjects of self-hypnosis and mental training taught in group sessions, with individual training in between according to a standard protocol, and integrated in daily life and work for six mo...

Cortisol (C) and dehydroepiandrosterone (DHEA) are recognized as the main fetal steroids, they likely to influence development have long-term effects on newborn hypothalamic-pituitary-adrenal axis (HPA) function. DHEA is often measured its sulfates expressed DHEA-S. Hair analysis represents a promising methodological approach for non-invasive measurement of allowing retrospective total exposure...