PurposeTo prospectively examine diagnostic error of neuro-ophthalmic conditions and resultant harm at multiple sites.DesignProspective, cross-sectional study.ParticipantsA total 496 consecutive adult new patients seen 3 university-based neuro-ophthalmology clinics in the United States 2019 to 2020.MethodsCollected data regarding demographics, prior care, referral diagnosis, final testing, treat...

Diagnostic biomarkers are used frequently in epidemiologic and clinical work. The ability of a diagnostic biomarker to discriminate between subjects who develop disease (cases) and subjects who do not (controls) is often measured by the area under the receiver operating characteristic curve (AUC). The diagnostic biomarkers are usually measured with error. Ignoring measurement error can cause bi...