Osteosarcoma, which is the most common type of highly malignant bone tumor in children and adolescents, has poor diagnosis and 2-year survival rates of 15-20% following surgery or radiotherapy, and has therefore generated marked attention. In order to investigate the potential biomarkers for diagnosing osteosarcoma, the expression profiling data from normal and disease tissues were compared, re...

Thyroid cancer is the commonest classical endocrine tumor, accounting for approximately 1% of all cancers. The diagnosis of thyroid cancer is typically made on cytopathologic features on fine needle aspiration or histological features on surgical samples. Following treatment of patients with thyroidectomy, and in some cases radioiodine, patients are monitored for disease recurrence using a vari...

Molecular pathology has become an essential adjunct in the realm of diagnostic histopathology. While gains in this field have been enjoyed in many areas, their impact has arguably been greatest felt in bone and soft tissue pathology. The purpose of this paper is to highlight the emerging role of molecular techniques in the context of paediatric bone pathology, discussing select syndromic and ne...

OBJECTIVE To evaluate the use of serum prolactin and total protein as a tumor marker in diagnosing uterine fibroid(s). METHODS A case control study was carried out from March 2004 to October 2005 at Al-Kharch Hospital in Baghdad, Iraq. Thirty-two patients with uterine fibroid(s) and 30 healthy normal women were involved in the study. Blood was collected from uterine fibroid patients before an...

Sepsis is a common and serious complication in intensive care unit patients. An important factor in optimizing survival rates in septic patients is the ability to start treatment early in the course of disease; there is, therefore, a need for accurate diagnostic tests. In recent years, there has been a move away from the rather vague and nonspecific signs that were previously used to diagnose s...

Periodontitis is one of the most common chronic inflammatory diseases. A number of putative bacterial pathogens have been associated with the disease and are used as diagnostic markers. In the present study, we compared the prevalence of oral bacterial species in the subgingival biofilm of generalized aggressive periodontitis (GAP) (n = 44) and chronic periodontitis (CP) (n = 46) patients with ...

BACKGROUND Our systematic review summarizes the evidence concerning the accuracy of serum diagnostic and prognostic tests for colorectal cancer (CRC). METHODS The databases MEDLINE and EMBASE were searched iteratively to identify the relevant literature for serum markers of CRC published from 1950 to August 2012. The articles that provided adequate information to meet the requirements of the ...