microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene expression regulators. Accurate identification of miRNA targets is crucial to understanding their function. Currently, hundreds of thousands of miRNA:gene interactions have been experimentally identified. However, this wealth of information is fragmented and hidden in thousands of manuscripts and raw next-generation s...

Human diseases are often diagnosed by determining levels of relevant enzymes and treated by enzyme inhibitors. We describe an assay suitable for both ultrasensitive enzyme quantification and quantitative inhibitor screening with unpurified enzymes. In the DNA-linked Inhibitor ANtibody Assay (DIANA), the target enzyme is captured by an immobilized antibody, probed with a small-molecule inhibitor...

Accurate modeling of masonry has been a major concern of the researchers in the past decades. Besides reinforced and unreinforced masonry structures, masonry can be found in frame structures as infill panels which are used as partitions and/or external walls. These elements role as a part of structure and introduce a large degree of nonlinearity into the system. In this study, a micro-modeling ...

Artikel ini mendokumentasikan upaya pengabdian masyarakat dalam mengembangkan aspek bisnis di Klinik Kesehatan Diana. Tujuan dari kegiatan adalah untuk memberikan pemahaman kepada Diana mengenai pengembangan dengan menggunakan Analisis SWOT. Metode yang digunakan meliputi observasi, wawancara, dan analisis data. Tim bekerja sama manajemen staf medis mengidentifikasi masalah potensi perbaikan be...

Differential expression analysis (DEA) is one of the main instruments utilized for revealing molecular mechanisms in pathological and physiological conditions. DIANA-mirExTra v2.0 (http://www.microrna.gr/mirextrav2) performs a combined DEA of mRNAs and microRNAs (miRNAs) to uncover miRNAs and transcription factors (TFs) playing important regulatory roles between two investigated states. The web...

Recently, the attention of the research community has been focused on long non-coding RNAs (lncRNAs) and their physiological/pathological implications. As the number of experiments increase in a rapid rate and transcriptional units are better annotated, databases indexing lncRNA properties and function gradually become essential tools to this process. Aim of DIANA-LncBase (www.microrna.gr/LncBa...