Cutaneous metastases of prostate cancer are a rare entity and mimic many other common cutaneous conditions such as cellulitis, zosteriform lesions, others, making it easy to misdiagnose. Recognition this condition is vital prevent delays in treatment, lesions usually appear late stages the disease associated with high fatality rate. Here we describe case 64-year-old man history diffuse metastat...

BACKGROUND Endothelial damage and activation may play central roles in the pathogenesis of systemic sclerosis (SSc) and are reflected by microparticles (MPs) and soluble selectins. The objective of this study was to determine if these potential biomarkers are associated with specific organ involvements or cutaneous subgroups of SSc patients. METHOD MPs in platelet-poor plasma from 121 patient...

INTRODUCTION In systemic sclerosis (SSc) little evidence for the effectiveness of anti-inflammatory and immunosuppressive therapy exists. The objective of this study was to determine the extent to which SSc patients are treated with corticosteroids and immunosuppressive agents. METHODS Data on duration and dosage of corticosteroids and on the type of immunosuppressive agent were analyzed from...

kindler syndrome (ks) is a rare, autosomal recessive genodermatosis characterized by skin blistering and photosensitivity in infancy, progressive poikiloderma, and diffuse cutaneous atrophy. it affects the skin, mucous membranes, and oral cavity and is caused by mutations in the kind1 gene on 20p12.3. the first case of ks associated with periodontitis was reported in 1996, and have been infrequ...

kindler's syndrome is a rare entity of unknown cause characterized by acral blisters early in life followed by progressive diffuse poikiloderma and cutaneous atrophy. the inheritance pattern of this syndrome is not clear. we report four iranian siblings (three boys and one girl) with this syndrome, who were the result of a consanguineous marriage. in addition to the usual manifestations of the ...

OBJECTIVE A prospective observational study of mycophenolate mofetil (MMF) treatment in patients with diffuse progressive cutaneous systemic sclerosis (SSc) of recent onset. METHODS Twenty-five previously untreated consecutive patients with recent-onset (< 24 mo) diffuse progressive cutaneous SSc received MMF as the only disease-modifying therapy. Modified Rodnan skin score (mRSS) and affecte...

The skin represents one of the organs in which the vast majority of diseases are associated with some manner of cutaneous lymphoid infiltration, or infiltration by other inflammatory cells. Just as benign processes can result in inflammatory disorders, so also atypical and malignant infiltrates of the skin can present a variety of different clinical manifestations. In addition to the classic in...

This article briefly reviews current knowledge about leishmaniasis in Ecuadorproceeding from 1920, when the first human case was described, to the present. Regarding basic conditions, it appears that 34 of Ecuador’s 20 provinces have endemic leishmaniasis. Nationally, over 4,000 cases were registered in the 19831986 period. Of 260 cases cited in the literature from 1920 through 1987, 240 (92.3%...

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal diffuse large B-cell lymphoma (DLBCL) characterized by selective growth of neoplastic cells within the vascular lumen. IVLBCL involves all types of organs and mostly is associated with poor prognosis, but patients with cutaneous variant have significantly better survival. In this article we report a case of 80-year-old...