Collagen 1 (Col1) fibers play an important role in tumor interstitial macromolecular transport and cancer cell dissemination. Our goal was to understand the influence of Col1 fibers on water diffusion, and to examine the potential of using noninvasive diffusion tensor imaging (DTI) to indirectly detect Col1 fibers in breast lesions. We previously observed, in human MDA-MB-231 breast cancer xeno...

OBJECTIVE: To study the utility of diffusion-weighted magnetic resonance imaging in the differentiation between benign and malignant breast lesions. MATERIALS AND METHODS: Forty-five women (mean age, 46.1 years) with 52 focal breast lesions underwent diffusion-weighted magnetic resonance imaging. The calculation of apparent diffusion coefficient (ADC) was based on the ADC map reflecting five b ...

BACKGROUND AND PURPOSE Diffuse axonal injury (DAI) accounts for a significant portion of primary intra-axial lesions in cases of traumatic brain injury. The goal of this study was to use diffusion-weighted MR imaging to characterize DAI in the setting of acute and subacute traumatic brain injury. METHODS Nine patients ranging in age from 26 to 78 years were examined with conventional MR imagi...

These are the graphs of the diffusion property change due to planter flexion of the right ankle joint. White bars are the right to left ratio of diffusion properties including FA, λ1, λ2, λ3, and ADC at resting state. Gray bars are those at the contraction in GCM (a), and passive elongation in AT (b). In GCM, statistically significant elevations are seen in FA (P<0.05 *), λ1 (P<0.01 **), λ2 (P<...

The objective of this study was to evaluate the regional effects of bronchodilator administration in chronic obstructive pulmonary disease (COPD) using hyperpolarized helium-3 ((3)He) MRI apparent diffusion coefficient (ADC). Ten COPD ex-smokers provided written, informed consent and underwent diffusion-weighted, hyperpolarized (3)He MRI, spirometry, and plethysmography before and 25 ± 2 min af...

BACKGROUND AND PURPOSE Cortical venous reflux (CVR) is a high risk factor for aggressive behavior of intracranial dural arteriovenous fistulas (DAVF). The pathological conditions in brain tissue affected by CVR were investigated by diffusion-weighted magnetic resonance imaging. METHODS A retrospective review identified 56 patients with DAVFs who underwent diffusion-weighted imaging before tre...

Our objective was to evaluate the role of echoplanar diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps in the assessment of response of uterine fibroids and myometrium to uterine fibroid embolization (UFE). We evaluated 32 fibroids in 11 patients treated with UFE. Treated lesions had low ADC values compared to untreated lesions. Furthermore, ADC values of the myomet...

background and purpose : there has been no report in which preoperative evaluation of adc for prediction of post therapeutic outcome was presented. the aim of our study was to retrospectively evaluation the use of the apparent diffusion coefficient (adc) for the prediction of malignancy and the outcome of malignant astrocytic tumors. methods: we reviewed mri of 26 male and 14 female patients wi...

the goal is assessing the diffusion magnetic resonance imaging (dmri) method effi ciency in characterizing focal hepatic lesions (fhls). about 28-fhl patients were studied in radiology and clinical imaging department of our university hospital using 1.5 tesla mri system between january 2010 and june 2011. patients underwent hepatic mri consisting of dynamic t1- and t2-weighted imaging. the dmri...

Objective: The purpose of our study was to evaluate the utility of the apparent diffusion coefficient (ADC) value measurement in the diagnosis of peritoneal metastases on diffusion weighted magnetic resonance imaging. Materials and Methods: Diffusion weighted imaging with conventional magnetic resonance imaging sequences was performed on twenty consecutive oncology patients (group I) with perit...