In this perspective article, we introduce a potentially transformative DNA/RNA detection technology that promises to replace DNA microarray and real-time PCR for field applications. It represents a new microfluidic technology that fully exploits the small spatial dimensions of a biochip and some new phenomena unique to the micro- and nanoscales. More specifically, it satisfies all the requisite...

A new biochip for adherent cell trapping using micro patterned parylene-C is presented. We demonstrate the ability of micro patterned parylene-C films to provide an efficient positioning and orientation of cells. It is also possible to fix one cell separate from the others which may be crucial in the development of biodevices for the single-cell analysis. The developed method does not require a...

The optothermal properties of nanoparticles are of interest for biosensors and highly sensitive biochip applications. In this respect, the longitudinal resonance of Au nanorods was used to transform near infrared energy into thermal energy in a microfluidic chip. The resulting heat generated effectively caused pathogen lysis. Consequently the DNA was extracted out of the cell body and transferr...

This paper deals with the development of a biochip dedicated to fusion between two types of cells, in a highly parallelized way. The fusion process is initiated by an electric field pulse applied to cells paired in fluidic traps. The paper will present different strategies for the capture and pairing of cells prior to the electrofusion, combining fluidic and electrical forces. The design is hig...

DNA microarrays have become one of the most powerful tools in the field of genomics and medical diagnosis. Recently, there has been increased interest in combining microfluidics with microarrays since this approach offers advantages in terms of portability, reduced analysis time, low consumption of reagents, and increased system integration. Polymers are widely used for microfluidic systems, bu...

Digital Microfluidic Biochips (DMFBs) have been widely used in Lab-on-a-Chip (LoC) for disease diagnosis and treatment applications. Biological sample to be processed are originally analog continuous flow. To convert it into digital droplets for DMFB processing, a microfluidic droplet dispenser acting as an analog-to-digital converter (ADC) is needed. In this paper, a highthroughput analog-to-d...

This article contains schemes, original experimental data and figures for an integrated modularized microfluidic system described in "An integrated microfluidic system for bovine DNA purification and digital PCR detection [1]". In this data article, we described the structure and fabrication of the integrated modularized microfluidic system. This microfluidic system was applied to isolate DNA f...