Dilated cardiomyopathy can be the end-stage form and common denominator of several cardiac disorders of known cause, such as hypertensive, ischemic, diabetic and Chagasic diseases. However, some individuals have clinical findings, such as an increase in ventricular chamber size and impaired contractility (classical manifestations of dilated cardiomyopathy) even in the absence of a diagnosed pri...

OBJECTIVE The goal was to identify the clinical variables associated with establishing a cause of cardiomyopathy in children. METHODS The Pediatric Cardiomyopathy Registry contains clinical and causal testing information for 916 children who were diagnosed as having cardiomyopathy in North America between 1990 and 1995. Children with a causal diagnosis were compared with those without with re...

BACKGROUND TNF-like weak inducer of apoptosis (TWEAK) has been reported to predict mortality in patients with dilated cardiomyopathy. However, whether it can be used as a biomarker for disease monitoring or rather represents a risk factor for disease progression remains unclear. AIM OF THE STUDY To evaluate the potential of sTWEAK as a biomarker in patients with dilated cardiomyopathy. RESU...

Dilated cardiomyopathy can be the end-stage form and common denominator of several cardiac disorders of known cause, such as hypertensive, ischemic, diabetic and Chagasic diseases. However, some individuals have clinical findings, such as an increase in ventricular chamber size and impaired contractility (classical manifestations of dilated cardiomyopathy) even in the absence of a diagnosed pri...

This study was designed to determine the morphological correlate of chronic heart failure. Myocardial tissue from eight patients undergoing transplantation surgery because of end-stage dilated cardiomyopathy was investigated by electron microscopy and immunocytochemistry using monoclonal antibodies against elements of the cytoskeleton: desmin, tubulin, vinculin, and vimentin. The tissue showed ...

Dilated cardiomyopathy can be broadly defined as heart failure with an enlarged left ventricular chamber, but with no evidence of ischemic heart disease or myocardial infarction. Recent studies from patients and animal models show that dilated cardiomyopathy results in a decrease in myocardial content of adenosine-50-triphosphate (ATP) and phosphocreatine and a decrease in the capacity for mito...

Prevalence and Pathogenesis of Dilated Cardiomyopathy Cardiomyopathies are defined as myocardial disorders in which the heart is structurally and functionally abnormal. Morphologically defined subtypes include hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic cardiomyopathy, and left ventricular (LV) noncompaction cardiomyopathy, and each of these subtypes can be g...

Irreversible dilated cardiomyopathy due to thyrotoxicosis is an unusual clinical entity. We report this case of a young female who presented with congestive cardiac failure and was diagnosed as dilated cardiomyopathy due to thyrotoxicosis. Restoration of euthyroid levels did not revert the cardiomyopathy.

The book Drug Therapy in Dilated Cardiomyopathy and Myocarditis is one of 11 volumes in a series of monographs on basic and clinical cardiology. It deals with the traditional, novel, and experimental pharmacologic agents used to treat congestive heart failure (CHF) and myocarditis, and with the relationship between these two disorders. The precise definition of dilated cardiomyopathy differs ac...

results of the 41 patients with dcm, echocardiography examination revealed 11 patients (27%) without mitral regurgitation and 12 (29%) with mild, 11 (27%) with moderate, and seven (17%) with severe mitral regurgitation. all of the morphological and functional parameters of left ventricle, atrium and mitral valve in dcm patients were greater than those in healthy subjects (all p < 0.05), except ...