نتایج جستجو برای: diltiazem hcl
تعداد نتایج: 13544 فیلتر نتایج به سال:
The efficacy of a single oral dose combination of 120 mg diltiazem and 160 mg propranolol in terminating paroxysmal supraventricular tachycardia (PSVT) was evaluated in 15 patients. All 15 patients underwent electrical induction of PSVT that lasted longer than 15 min, and all underwent randomized crossover placebo and diltiazem and propranolol studies on 2 consecutive days. On each day PSVT was...
The antihypertensive effect of diltiazem (180-270 mg/day) and nifedipine (40-60 mg/day) in slow-release forms was assessed over 8 weeks in a double-blind parallel study in 40 subjects with essential hypertension at rest and during exercise. Blood pressure was comparably reduced in both groups at rest as well as during exercise. The responder rates (greater than or equal to 10% reduction in dias...
OBJECTIVE To evaluate whether the calcium-channel blocker diltiazem has protective effects against cisplatin-induced ototoxicity in a mouse model. STUDY DESIGN Original basic science in vivo investigation. SETTING Academic setting: Otolaryngology-Head and Neck Surgery laboratory at University of Connecticut Health Center. SUBJECTS Thirty-nine female CBA/J mice. METHODS Pure tone- or cli...
BACKGROUND Diltiazem is widely used to prevent radial artery spasm after coronary bypass grafting (CABG). However, recent in vitro and in vivo studies have shown that nitroglycerin is a superior conduit vasodilator compared to diltiazem. A clinical comparison of these agents in patients undergoing CABG has not been previously performed. METHODS One hundred sixty-one consecutive patients under...
Background. Diltiazem, a calcium channel blocker, has been shown to be safe and effective in the treatment of patients in atrial fibrillation and/or atrial flutter. However, there have been no pharmacokinetic/pharmacodynamic studies of diltiazem in these patients. Methods and Results. The pharmacokinetics and pharmacodynamics of intravenous diltiazem were determined in 32 patients with atrial f...
Background. After long-term treatment with continuous ambulatory peritoneal dialysis (CAPD), some patients may develop peritoneal fibrosis. Peritoneal mesothelial cells (PMCs) participate in the inflammatory reactions in the peritoneal cavity, and transforming growth factor-b1 (TGF-b1) and interleukin-1b (IL-1b) are involved in peritoneal fibrosis. Diltiazem is used frequently in patients with ...
PURPOSE Calcium channel blockers diltiazem and nitrate have been used as selective coronary vasodilators for patients with significant coronary artery spasm (CAS). However, no study has compared the efficacy of diltiazem alone versus diltiazem with nitrate for long-term clinical outcomes in patients with CAS. MATERIALS AND METHODS A total of 2741 consecutive patients without significant coron...
BACKGROUND Topical nitrates lower anal sphincter pressure and heal anal fissures, but a majority of patients experience headache. The internal anal sphincter has a calcium dependent mechanism to maintain tone, and also receives an inhibitory extrinsic cholinergic innervation. It may therefore be possible to lower anal sphincter pressure using calcium channel blockers and cholinergic agonists wi...
The benzothiazepine diltiazem blocks ionic current through L-type Ca(2+) channels, as do the dihydropyridines (DHPs) and phenylalkylamines (PAs), but it has unique properties that distinguish it from these other drug classes. Wild-type L-type channels containing alpha(1CII) subunits, wild-type P/Q-type channels containing alpha(1A) subunits, and mutants of both channel types were transiently ex...
pharmacokinetic studies of diltiazem. CYP3A4, a key enzyme in the metabolism of diltiazem is mainly located in liver, but it is also expressed in the small intestine (Watkins et al., 1987; Pichard et al., 1990; Kolars et al., 1992). Thus, diltiazem could be metabolized in both the small intestine and the liver (Homsy et al., 1995a; Homsy et al., 1995b; Lefebvre et al., 1996). Lee et al. (1991) ...
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