5521 Background: This study evaluated the relative efficacy of magic mouthwash (diphenhydramine, dexamethasone and nystatin) plus sucralfate compared to benzydamine hydrochloride in reducing the severity of patient-reported symptoms of mucositis. METHODS Patients receiving primary or post-operative radiotherapy (RT) for squamous cell carcinoma of the head and neck were stratified according to...

BACKGROUND This study was designed to examine the analgesic and dose-related antiemetic efficacy of diphenhydramine-morphine mixture for intravenous patient-controlled analgesia (PCA). METHODS Healthy women, undergoing abdominal total hysterectomy were recruited to this double-blinded randomized placebo-controlled study. Patients were randomly allocated to one of three groups (n=40 each). In ...

To elucidate the local anesthetic mechanism of diphenhydramine, its effects on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion (DRG) neurons were examined by the whole-cell voltage clamp method. Diphenhydramine blocked TTX-S and TTX-R sodium currents with K(d) values of 48 and 86 microM, respectively, at a holding potential of -80 mV...

To determine whether neuronal histamine influences development of histamine H-1 receptors in the rat brain, neonates were given diphenhydramine, an H-1 antagonist, daily for the first 21 days of postnatal life. In control rats, specific H-1 binding of [3H]mepyramine in whole brain was low at birth and increased progressively toward adult levels by the end of the 3rd week. Animals treated with d...

Despite the large number of elderly patients in nursing homes and the intensity of medication use there, few current data are available on patterns of medication use in this setting. We studied all medication use among 850 residents of 12 representative intermediate-care facilities in Massachusetts. Data on all prescriptions and patterns of actual use were recorded for all patients during one m...

The histamine I receptor antagonist diphenhydramine is a freely available, over the counter medication for sleep and the most frequently used antihistamine drug. It inhibits the fast sodium channels and, at higher concentrations, the repolarising potassium channels, particularly Ikr which leads to prolongation of the action potential and the QT interval. The toxicity of diphenhydramine is dose-...

conclusions herbal compounds, such as zm mixtures, are acceptably efficacious in cough relief with fewer adverse effects than chemical compounds in the treatment of cold-related cough, especially in infants and younger children. patients and methods a total of 52 pediatric patients (2 - 12 years old) with common colds were included in the study. the patients were randomly divided into two treat...

A fatal poisoning case involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed that the concentrations of diphenhydramine, paroxetine, phenobarbital, diazepam and its metabolites (nordiazepam and temazepam) in the femoral blood were 9.19 μg/ml, 1.02 μg/ml, 19.9 μg/ml, 0.26 μg/ml, 8.55 μg/ml and 2.69 μg/ml, respectively. We concluded that the cause of death...