Cysteine self assembled monolayer-modified gold (Cys/Au) electrode is used to immobilize superoxide dismutase (SOD) and establish a direct electron transfer between enzyme and electrode surface. However, due to the redox activity of copper ion on Cys monolayer, there would be an ambiguity in electrochemical studies of immobilized SOD on Cys/Au electrode. We designed a series of experiments to c...

F or this special issue of PNAS, it seems appropriate to begin with a brief commentary on the path(s) leading to where the discipline of electrochemistry is today. The papers in this issue serve as a sampling of the current themes and directions; we thank the authors for their contributions. We should also point to a nice collection of historical perspectives gathered together by Leddy et al. (...

This review regards the use of dynamic electrochemistry to study the mechanism of redox enzymes, with exclusive emphasis on the configuration where the protein is adsorbed onto an electrode and electron tranfer is direct. We still often come across the statement these days that redox enzymes are too large and too fragile to interact directly with a metallic electrode without being at least part...