نتایج جستجو برای: directed evolution

تعداد نتایج: 492112  

Journal: :Nature Reviews Molecular Cell Biology 2009

Journal: :Microbiology and Molecular Biology Reviews 2005

Journal: :Proceedings of the National Academy of Sciences 2002

Journal: :Journal of Artificial Intelligence and Soft Computing Research 2017

Journal: :Current Opinion in Structural Biology 2021

De novo enzymes can be created by computational design and directed evolution. Here, we review recent insights into the origins of catalytic power in evolved designer to pinpoint opportunities for next-generation designs: Evolution precisely organizes active sites, introduces H-bonding networks, invokes electrostatic catalysis, creates dynamical networks embedding site a reactive protein scaffo...

2008
David M. Knapp

INTRODUCTION Stereoselective chemical reactions have become extremely important in both academic and industrial settings for the synthesis of useful molecules. Catalytic reactions are of particular importance due to their capacity to effect otherwise impossible transformations using substoichiometric quantities of the catalyst. Traditionally, transition metal catalysts have played a central rol...

2011
Diana Maté Eva García-Ruiz Susana Camarero Miguel Alcalde

Fungal laccases are generalists biocatalysts with potential applications that range from bioremediation to novel green processes. Fuelled by molecular oxygen, these enzymes can act on dozens of molecules of different chemical nature, and with the help of redox mediators, their spectrum of oxidizable substrates is further pushed towards xenobiotic compounds (pesticides, industrial dyes, PAHs), b...

Journal: :Trends in biotechnology 1999
C Schmidt-Dannert F H Arnold

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