Both society and industry are interested in increasing the safety of pharmaceuticals. Potentially dangerous compounds could be filtered out at early stages of R&D by computer prediction of biological activity and ADMET characteristics. Accuracy of such predictions strongly depends on the quality & quantity of information contained in a training set. Suggestion that some relevant chemical inform...

We characterize the properties of optimal accounting rules in a signaling game where an impatient entrepreneur sells shares to competitive investors. The entrepreneur can signal her private information about the fundamental of the rm by retaining a fraction of the shares. In addition, she can commit to disclosing information according to a set of accounting rules chosen ex ante. Information dis...

Abstract The seller of an asset has the option to buy hard information about value from intermediary. can then disclose this before selling in a competitive market. We study how intermediary designs and sells robustly maximize intermediary's revenue across all equilibria. Even though could use accurate test that reveals asset’s value, we show robust maximization leads noisy with continuum possi...

PURPOSE This study assessed the effect of preparation design on marginal adaptation and also compared the sensitivity and specificity of clinical evaluation techniques for marginal accuracy of cast restorations to stereomicroscopy. MATERIALS AND METHODS Three Ivorine molar teeth of different designs were prepared. (A)-A complete crown preparation with buccal shoulder and beveled finish line. ...

In this study, we explore the association between intellectual capital (IC) efficiency of firms and their voluntary disclosure environmental, social, governance (ESG) information, using data on Jordanian listed value-added coefficient (VAIC) model with its three components human, structural, relational (HCE, SCE, RCE, respectively). We find that disclosing environmental information is unrelated...

Collecting and displaying product reviews written by consumers is a common practice for many retail websites. These websites, however, differ in their choice to reveal aggregate review statistics on the product list displayed while consumers browse or search to make initial product selections. This study proposes an analytical model to examine the conditions in which revealing average star rati...

Abstract Research suggests that earnings-disclosure-related litigation causes managers to reduce subsequent disclosure, perhaps stemming from a belief even their good faith disclosures will cause them trouble. This paper considers unexplored dimensions of disclosure and alternative channels provide additional evidence speaks how shapes managers’ strategies. Consistent with Skinner (1994)’s clas...

We describe a protocol for disclosing unfavorable information-"breaking bad news"-to cancer patients about their illness. Straightforward and practical, the protocol meets the requirements defined by published research on this topic. The protocol (SPIKES) consists of six steps. The goal is to enable the clinician to fulfill the four most important objectives of the interview disclosing bad news...