The emergence in 1976 of Doug Lenat's mathematical discovery program AM [Len76] [Len82a] was met with suprise and controversy; AM's performance seemed to bring the dream of super-intelligent machines to our doorstep, with amazingly simple methods to boot. However, the seeming promise of AM was not borne out: no generation of automated super-mathematicians appeared. Lenat's subsequent attempts (...

The Grid is the computing and data management infrastructure, which is transforming science, business, health and society. This paper deals with a challenging task addressing knowledge discovery in data repositories within the Grid. It gives an overview about the architecture of a novel Grid knowledge discovery system, the collaboration of the designed services and the concepts of controlling t...

We consider peer-to-peer and distributed networks where a large number of objects (such as users, information and applications) are distributed and dynamically move. In such a distributed network environment, the ability to discover objects that match given query criteria such as a set of keywords is highly desirable. In this paper, we propose a discovery mechanism that is scalable, adaptable a...

In this protocol, we report a novel approach for the synthesis of a new class of heterocyclic 1H-1,2,3-triazole-modified peptidomimetic compounds. The process consists of an Ugi four-component condensation reaction of amines, an isocyanide, an aldehyde and acids followed by a Huisgen 1,3-dipolar cycloaddition reaction with an azide group in the presence of a catalytic amount of CuSO4</...

despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...

the rapid growing of information technology (it) motivates and makes competitive advantages in health care industry. nowadays, many hospitals try to build a successful customer relationship management (crm) to recognize target and potential patients, increase patient loyalty and satisfaction and finally maximize their profitability. many hospitals have large data warehouses containing customer ...

the ability to discover services in mobile ad hoc network (manet) is a major prerequisite. cluster basedcross layer intelligent service discovery for manet (cbisd) is cluster based architecture, caching ofsemantic details of services and intelligent forwarding using network layer mechanisms. the cluster basedarchitecture using semantic knowledge provides scalability and accuracy. also, the mini...

Components are developed as important and big autonomous and customizable software units. The successfulness of the reuse is important and depend on first the efficiency of the search procedure, second in the success of integration of the discovered component in system engineering. In order to find components that best meet their functionalities and QoS requirements, the discovery process need ...

background and objectives: arteriovenous fistula is a popular vascular access method for surgical treatmentof hemodialysis patients. the method, however, is associated with a high rate of early failure varying in the range of 20-60%. predicting early arteriovenous fistula failure and its risk factors can help reduce its incidence, its hospitalization rate, and associated costs. in this study, w...