PURPOSE This study investigated the safety and potential retinal toxicity of intravitreally administered erythropoietin (EPO) in a rodent animal model. METHODS Forty-two healthy Sprague-Dawley rats were divided into one of 7 groups (N = 6 per group): control, sham injection, vehicle injection, and EPO injections of 50 ng (5 U), 100 ng (10 U), 250 ng (25 U), and 625 ng (62.5 U). Only the right...

Purpose: To investigate the pharmacokinetic mechanism of interaction between magnolol and piperine when co-administered to rats. Methods: The rats were divided into five groups as follows: magnolol group (625 mg/kg); low dose of piperine group (20 mg/kg); high dose of piperine group (40 mg/kg); low dose of piperine + magnolol group; or high dose of piperine + magnolol group. Plasma samples were...

A 49-year-old female took low-dose pergolide (625 microg daily) for approx. 5 years (approximately cumulative dose 1.140 g/5 years) for the treatment of restless legs syndrome. She developed moderate to severe mitral and aortic valve insufficiency, requiring semi-urgent double-valve replacement. The initial diagnosis of rheumatic valve disease was refuted on histological examination of the valv...

The public does not yet know the potential of Eugenia polyantha as an alternative medicine for diabetes mellitus. In fact, content chemical compounds such flavonoids in can minimize damage to pancreas. This study aimed determine antidiabetic activity ethanolic extract leaf against streptozotocin-induced Wistar rats. sample this were male white rats strain, consisting 30 It was divided into 6 te...

Richard Seonghun Nho* and Mark Peterson Running title : Integrin-collagen interaction suppresses 4EBP-1 function Present address: Department of Medicine, University of Minnesota, 420 Delaware Street, SE, Minneapolis, Minnesota 55455 Address of corresponding author: Richard Seonghun Nho, Box 276, University of Minnesota, 420 Delaware Street SE., Minneapolis, Minnesota, 55455 Telephone: 612-625-0...

1,3-Butadiene, a large-production volume chemical used mainly in the manufacture of synthetic rubber, was found to induce multiple-organ carcinogenicity in male and female B6C3F1 mice at exposure concentrations (625 and 1250 ppm) equivalent to and below the OSHA standard of 1000 ppm. Since this study was terminated after 60 weeks of exposure because of reduced survival due to fatal tumors, and ...

conclusions higher prevalence of t. gondii in patients with ad compared to controls showed the possible impact of this parasite in ad, which may exacerbate symptoms, and this requires special attention of specialists and patient families. results the overall prevalence of t. gondii infection in patients with ad and the control group, using elisa assay, was obtained as 66.6% (58/87) and 56.32% (...

The cost of producing the dialysis solutions is approximately one-fourth that of proprietary dialysis fluids. This includes the price of labour, but not that of laboratory determinations for quality control. The total price of the initial equipment such as mixingtanks, a pump, filter holders, and a dozen carboys is about £625 ($1,500). Many hospital pharmacies carry these items as part of their...

T. SIVARUBAN, S. BARATHY, M. ARUNACHALAM, K. VENKATARAMAN & K.G. SIVARAMAKRISHNAN 1Department of Zoology, The American College (Autonomous), Madurai-625 002, India 2Department of Zoology, The Madura College (Autonomous), Madurai-625 011, India 3Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi 627 412, India 4Department of Zoology, Madras Chris...