Cytomegalovirus (CMV) disease is a leading cause of infectious morbidity and mortality in patients with a kidney transplant. Before the advent of specific prophylaxis and therapy, more than half of the patients who had not been exposed to CMV prior to kidney transplantation developed primary disease and ~20% of patients with prior evidence of exposure developed reactivation disease [1]. Mortali...

In this 2022 Update of Version 2020 the VI Consensus Brazilian Society Bone Marrow Transplantation (SBTMO) for Graft-versus-Host-Disease (GVHD), we seek to provide evidence-based guidance on all novel and clinically relevant advancements in both prophylaxis therapy Graft-versus-Host Disease those who delve into field Hematopoietic Stem Cell Transplantation.

Post-transplant hepatitis B virus (HBV) recurrence prophylaxis is a sine qua non of liver transplantation for HBV-related liver disease because of high rate and aggressive course of HBV recurrence. Hepatitis B immune globulin (HBIG) is a polyclonal immune globulin solution obtained from plasma, donated by individuals with high titres of anti-HBs (hepatitis B antibody). Although it was being use...

OBJECTIVE To determine the incidence of haemorrhagic disease of the newborn in the British Isles, study risk factors, and examine the effect of vitamin K prophylaxis. DESIGN Prospective survey of all possible cases of haemorrhagic disease of the newborn as reported by consultant paediatricians using the monthly notification cards of the British Paediatric Surveillance Unit and a follow up que...

This study assessed the incidence of cytomegalovirus (CMV) disease and associated outcomes after oral ganciclovir prophylaxis in renal transplantation. A retrospective analysis was performed of all adult renal transplant recipients at a single transplant center transplanted between August 16, 1996, and December 31, 2000. CMV disease prophylaxis included ganciclovir 1000 mg orally thrice daily p...

a total of70 children aged 6 to 15 years with rheumatic fever and completed in-hospital data were reviewed from 19xx to 1993. in 5x.6% of patients this was the first attack of disease, while in 41.4'10 the episode represented a recurrence. noncompliance of antimicrobial prophylaxis was noted in all of the subjects with recurrences. 61.4% of cases gave a previous history of sore throat, and...

OBJECTIVE To estimate the cumulative exposure to bacteraemia from dental procedures currently recommended for antibiotic prophylaxis and compare this with cumulative exposure from dental procedures not recommended for prophylaxis. DESIGN Retrospective analysis. SETTING University and teaching hospital maxillofacial and dental department. PATIENTS 136 children with severe congenital cardia...

BACKGROUND Studies have not established the optimal role for prophylaxis after surgery for Crohn's disease. Some suggest treatment should be initiated within the first month after surgery, whereas others advocate targeted treatment after endoscopic recurrence. In the present study, we compared the efficacy of these competing approaches. METHODS One hundred and ninety-nine Crohn's disease pati...

PURPOSE OF REVIEW Lung transplantation remains the main therapy for patients with end-stage lung disease, yet survival remains limited by infection and chronic rejection. Invasive fungal infection, especially invasive aspergillosis, continues to cause a high rate of mortality after lung transplantation, and there is evidence that fungal colonization in itself may have a negative impact as well....

Invasive fungal disease (IFD), predominantly aspergillosis, is associated with significant morbidity and mortality in immunocompromised patients, especially those with haematological malignancies and recipients of allogeneic haematopoietic stem cell transplantation. There has been a great deal of scientific debate as to the effectiveness of antifungal prophylaxis in preventing infection in diff...