Centrosome duplication is licensed by the disengagement, or 'uncoupling', of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement. Here, we show that premature disengagement results from untimely activation of the anaphase-promoting complex (APC/C), leading to securin degradation and release of active separase. Although APC/C activation du...

CASSIE BARASH FORD: ERP Indices of Attentional Disengagement and Filtering Following Reflexive Attentional Capture (Under the direction of Joseph B. Hopfinger) The goal of this study was dissociate the mechanism of target selection when distractor suppression is required from spatial disengagement and reorienting. Specifically, we aimed to elicit and compare online event-related potential (ERP)...

The centrosome, consisting of a pair of centrioles surrounded by pericentriolar material, directs the formation of bipolar spindles during mitosis. Aberrant centrosome number can promote chromosome instability, which is implicated in tumorigenesis. Thus, centrosome duplication needs to be tightly regulated to occur only once per cell cycle. Separase, a cysteine protease that triggers sister chr...

During search, the disengagement of attention is automatically delayed when a fixated but task-irrelevant object shares features of the search target. We examined whether delayed disengagement based on top-down attention set is potentially functional, resulting in additional processing of the fixated item. To accomplish this, we adapted the oculomotor disengagement paradigm. Participants saccad...

INTRODUCTION The objective of this analysis was to identify points of disruption within the prevention of mother-to-child transmission (PMTCT) continuum from combination antiretroviral therapy (CART) initiation until delivery. METHODS To address this objective, the electronic medical records of all antiretroviral-naïve adult pregnant women who were initiating CART for PMTCT between January 20...

INTRODUCTION Recent international guidelines call for expanded access to triple-drug antiretroviral therapy (ART) in HIV-positive women during pregnancy and postpartum. However, high levels of non-adherence and/or disengagement from care may attenuate the benefits of ART for HIV transmission and maternal health. We examined the frequency and predictors of disengagement from care among women ini...