This article is focused on the epidemiological evidence on the health impacts related to disinfection by-products (DBPs) in swimming pools, which is a chemical hazard generated as an undesired consequence to reduce the microbial pathogens. Specific DBPs are carcinogenic, fetotoxic and/or irritant to the airways according to experimental studies. Epidemiological evidence shows that swimming ...

Exposure to disinfection by-products (DBPs) of drinking water is multiroute and occurs in households serviced by municipal water treatment facilities that disinfect the water as a necessary step to halt the spread of waterborne infectious diseases. Biomarkers of the two most abundant groups of DBPs of chlorination, exhaled breath levels of trihalomethanes (THMs) and urinary levels of two haloac...

Chlorination disinfection by-products (CDBPs) are produced during the treatment of water with chlorine to remove bacterial contamination. CDBPs have been associated with an increased risk of bladder cancer. There is also some evidence that they may increase the risk of pancreatic cancer. We report results from a population-based case-control study of 486 incident cases of pancreatic cancer and ...

Infants are extremely vulnerable to certain pesticide exposures because they are still developing the ability to produce the enzyme para­ oxonase­1 (PON1), which detoxifies certain organophosphate pesti­ cides such as chlorpyrifos and diazinon. A study published in 2003 indicated that children may reach near­adult levels of PON1 activ­ ity by age 2 years. But a new larger­scale study of partici...

We report the formation of trihalomethanes and other disinfection by-products from four polyfunctional terpenoids during simulated chlorination of natural waters. Complex suites of products were identified by closed loop stripping analysis (CLSA)/gas chromatography-mass spectrometry (GC-MS) from halogenation of beta-carotene and retinol. beta-Ionone appeared to be a key intermediate in the halo...

Previous research has suggested that exposure to elevated levels of drinking water disinfection by-products (DBPs) may cause pregnancy loss. In 2000-2004, the authors conducted a study in three US locations of varying DBP levels and evaluated 2,409 women in early pregnancy to assess their tap water DBP concentrations, water use, other risk factors, and pregnancy outcome. Tap water concentration...

Chlorine was first used to purify water in the United States almost 100 years ago (1). Since that time, the technique has been improved upon and its use expanded so that most water systems today are disinfected (1). In 1995, approximately 64 percent of community water systems (systems that provide water to the same people year-round) specifically added chlorine as a disinfectant, and the remain...

Drinking water disinfection by-product (DBP) occurrence research is important in supporting risk assessment and regulatory performance assessment. Recent DBP occurrence surveys have expanded their scope to include non-regulated priority DBPs as well as regulated DBPs. This study applies a Box-Cox transformed multivariate normal model and data augmentation methods for left-censored and missing o...

rd HJ. Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling. Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform. et al. Bladder cancer and exposure to water disinfection by-products through ingestion, bathing, showering, and swimming in pools. AD. Th...