Sertraline Hydrochlride, the selective serotonin reuptake inhibitor (SSRI) is widely used in treatment of depression. Though Sertraline Hydrochloride is well absorbed after oral dosing, there is a first pass metabolism leading to a reduced bioavailability of the drug (44%). Therefore, the present investigation is concerned with the development of Fast Dissolving Tablets of Sertraline Hydrochlor...

The purpose of this research was to develop mouth dissolve tablets of cinnarizine by effervescent, superdisintegrant addition and sublimation methods. All the three formulations were evaluated for disintegration time, hardness and friability, among these superdisintegrant addition method showed lowest disintegration time; hence it was selected for further studies. Further nine batches (B1-B9) w...

The new CPEM (cooked potato effective mass) method was used to study the sloughing of a potato variety grown in two successive years in six regimes given by different levels and forms of fertilisation and irrigation. The sloughing process is characterized by the cooking time, i.e. the starting point of disintegration, and by the speed of disintegration. Both parameters are also evaluated in dep...

WE HAVE recently reported that marihuana extract, calibrated for content of (—)Al-tetrahydrocannabinol (THC), significantly impaired the serial coordination of cognitive operations during a task that required sequential adjustments in reaching a goal.' Our term for this mental incoordination is temporal disintegration. From a cognitive standpoint, temporal disintegration means that the individu...

Aceclofenac, a non-steroidal antiinflammatory drug, is used for posttraumatic pain and rheumatoid arthritis. Aceclofenac fast-dispersible tablets have been prepared by direct compression method. Effect of superdisintegrants (such as, croscarmellose sodium, sodium starch glycolate and crospovidone) on wetting time, disintegration time, drug content, in vitro release and stability parameters has ...

The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioav...

An explicit evaluation of the spin asymmetry of the deuteron and the associated GDH sum rule is presented which includes disintegration, single and double pion and eta production. For the GDH integral a large cancellation is found between the disintegration channel and the meson production channels. Furthermore, first results for the contribution of the disintegration channel to the generalized...

The notions of disintegration and Bayesian inversion are fundamental in conditional probability theory. They produce channels, as conditional probabilities, from a joint state, or from an already given channel (in opposite direction). These notions exist in the literature, in concrete situations, but are presented here in abstract graphical formulations. The resulting abstract descriptions are ...

a research program was conducted on different clay-bearing rocks selected from the ilam, sarpol-e zahab and tajarak regions (iran) to predict their slaking characteristics. the new durability apparatus (nested mesh drums) separates disintegrated particles varying from > 25.4 to < 2 mm as the drums were rotated. on the basis of the particle size distribution, the disintegration ratio (dr) was us...