The aim of this study was to investigate if the changes made in the specifications of the disintegration procedure impact the performance of the disintegration test described in USP chapters <701> and <2040>. Different tablets and capsules were produced, and their disintegration times were determined. The following disintegration time parameters were analyzed: volume of the immersion fluid, typ...

A molecular systematic study of Scrophulariaceae sensu lato using DNA sequences of three plastid genes (rbcL, ndhF, and rps2) revealed at least five distinct monophyletic groups. Thirty-nine genera representing 24 tribes of the Scrophulariaceae s.l. (sensu lato) were analyzed along with representatives of 15 other families of Lamiales. The Scrophulariaceae s.s. (sensu stricto) include part or a...

Conditional probability distributions seem to have a bad reputation when it comes to rigorous treatment of conditioning. Technical arguments are published as manipulations of Radon±Nikodym derivatives, although we all secretly perform heuristic calculations using elementary de®nitions of conditional probabilities. In print, measurability and averaging properties substitute for intuitive ideas a...

Article history: Received on: 09/07/2013 Revised on: 16/09/2013 Accepted on: 03/10/2013 Available online: 31/10/2013 The aim of the study was to develop a formulation of Ticagrelor 90 mg tablets that is equivalent to the reference product using similar excipients to match the in-vitro dissolution profile. A compressed coated tablet was formulated consisting of Ticagrelor and excipients conformi...

The radiations from 60-day Sb lN have been studied by several investigators. H ales and Jordan [2] used a 1800 spectrometer to study the beta spectrum of Sb124. Tbey report the presence of two components with maximum cnergies at 0.74 ± O.03 and 2.45 ± 0.07 million electron volts (NIev) . ~1iller and Omtiss [3], u ing a thin magnetic len spectrometer , also ob erved a complex beta specLrum, but ...

Lamiales sensu APG II (The Angiosperm Phylogeny Group, 2003) constitute a major clade of flowering plants, with approximately 17,800 species (Judd & al., 2002) and 23 families, representing 12.3% of eudicot diversity (Stevens, 2001, onwards). They belong to a major asterid clade, the Lamiids (Bremer & al., 2002). The monophyly of Lamiales is comparatively uncontroversial and well supported by m...

N a table showing the existing atomic nuclei it is observed that many groups of isobars occur, the term isobar referring to nuclei of the same atomic weight but different atomic number. It is unreasonable to assume that all isobars have exactly the same energy; one of them therefore will have the lowest energy, the others are unstable. The question arises why the unstable nuclei are in reality ...

The disintegration of mesotrons at the end of their range was investigated by means of an improved arrangenxent of the type already described by the author. The absorption of a mesotron by a block of aluminum or iron is recorded by a system of coincidence and anticoincidence counters. Another system of counters and circuits registers the delayed emission of a particle, which is interpreted as t...