Infection with Leishmania amazonensis and L. mexicana may lead to diffuse cutaneous leishmaniasis. The cure is exceptional, especially for the strange case of this lady. Case report: patient acquired disease in childhood remained lesions over 30 years, albeit several treatments. She worsened after a pregnancy, developing disseminated lesions. Miltefosine amphotericin B pentamidine resulted remi...

69-year-old male patient, with history of multiple furunles for two months, without improvement after the use of ephalexin and amoxicillin/clavulanate for 20 days, and daily ever for a week. On dermatological examination, multiple lcerovegetative and ulcero-crusted cutaneous lesions on the ace, ears, scalp, back, upper and lower limbs and genitalia ere observed (Figs. 1 and 2). There was no lym...

Leishmania (V.) braziliensis and Leishmania(L.) amazonensis are the most pathogenic agents of American Cutaneous Leishmaniasis in Brazil, causing a wide spectrum of clinical and immunopathological manifestations, including: localized cutaneous leishmaniasis (LCLDTH+/++), borderline disseminated cutaneous leishmaniasis (BDCLDTH±), anergic diffuse cutaneous leishmaniasis (ADCLDTH-), and mucosal l...

Visceral leishmaniasis (VL), also known as Kala-Azar, is a disseminated protozoal infection caused principally by Leishmania donovani and Leishmania infantum (known as Leishmania chagasi in South America). The therapeutic options for VL are diverse and depend on different factors, such as the geographical area of the infection, development of resistance to habitual treatments, HIV co-infection,...

Diffuse cutaneous leishmaniasis is a rare entity characterized by disseminated cutaneous nodules associated with specific anergy to leishmanial antigens. A low but not absent IFN-gamma expression by cells present in cutaneous lesions has been documented during the active phase of diffuse cutaneous leishmaniasis. In this study we confirm this observation, and extend it by showing a similar patte...

Governed by parasite and host factors and immunoinflammatory responses, the clinical spectrum of leishmaniasis encompasses subclinical (inapparent), localised (skin lesions), and disseminated infection (cutaneous, mucosal, or visceral). Symptomatic disease is subacute or chronic and diverse in presentation and outcome. Clinical characteristics vary further by endemic region. Despite T-cell-depe...

The Medical Journal of Australia ISSN: 0025729X 19 March 2007 186 6 315-317 ©The Medical Journal of Australia 2007 www.mja.com.au Lessons from Practice humans and animal reservoirs in tropical and subtrop About 1.5 million new cases are documented each yea and over 350 million people live in areas of active para sion. Leishmaniasis is one of the top five diseases ta World Health Organization Sp...

Fevers of unknown origin (FUO) in HIV/AIDS patients are due to the same infectious causes that are common in this subset of compromised hosts but manifest clinically as prolonged fevers. In North America, the most common etiologies of FUO in HIV/AIDS are due to intracellular pathogens, i.e., disseminated Mycobacterium avium-intracellulare, Pneumocystis carinii pneumonia (PCP), fungi or cytomega...

There is growing concern regarding the emergence of visceral leishmaniasis (VL), a disseminated parasitic disease caused by protozoa of the genus Leishmania, as an opportunistic infection in immunocompromised patients. This association has been principally studied in the context of human immunodeficiency virus infection, but VL has also been reported in patients undergoing treatment with immuno...

Male of 52 year old with chronic alcoholism and ulcerated lesion on the face and disseminated nodular skin lesions, underwent to biopsy of ulcer edges where was observed a concomitant epidermoid malignancy with Leishmania (L.). Besides others, biopsies of nodule in the periumbilical region, lymph node and bone marrow were assayed, and all biopsies had abundant amastigotes. The amplified Polymer...