I- Dmo I is a homing enzyme of the LAGLI-DADG type that recognizes up to 20 bp of DNA and is encoded by an archaeal intron of the hyperthermophilic archaeon Desulfurococcus mobilis . A combined mutational and DNA footprinting approach was employed to investigate the specificity of the I- Dmo I-substrate interaction. The results indicate that the enzyme binds primarily to short base paired regio...

OBJECTIVE To evaluate modifications of arterial structure, gene expression, and function in our model of rats exposed to maternal diabetes. RESEARCH DESIGN AND METHODS Morphometric analyses of elastic vessels structure and determination of thoracic aortic gene expression profile with oligonucleotide chips (Agilent, G4130, 22k) were performed before the onset of established hypertension (3 mon...

BACKGROUND/AIMS Retinal photography with a non-mydriatic camera is the method currently employed for diabetic retinography (DR) screening. We designed this study in order to evaluate the prevalence and severity of DR, and associated risk factors, in patients with type 2 diabetes (T2DM) screened in Catalan Primary Health Care. METHODS Retrospective, cross-sectional, population based study perf...

PURPOSE The arterial pulsatility index (PI) is measured by transcranial Doppler ultrasonography (TCD) and is postulated to reflect the vascular resistance distal to the artery being examined. An increased PI of the intracranial artery is often reported with diabetes mellitus (DM), old age, hypertension, intracranial hypertension, vascular dementia, and small artery disease. Microvascular compli...

INTRODUCTION We describe a proactive method using electronic patient records (EPR) to identify pseudophakic patients with diabetic macular oedema (DMO) that might benefit from treatment with 0.2 µg/day fluocinolone acetonide (FAc; ILUVIEN(®)) implant. METHODS Our EPR audit tool (Medisoft(®)) identified diabetic patients (May 2011-December 2014) with National Screening Committee-confirmed grad...

Diabetic macular oedema (DMO) presents an enormous rise in the last decades with an increasing number of diabetic patients. It has a negative impact on the health-related quality of life beside the related visual loss. Additionally, it incurs more health centre visits, higher health costs, and lower working performance. Therefore, early diagnosis and preventive measures gain more and more impor...

How DMO managers should evaluate success is a topic of much scholarly debate. Increasingly, there is a suggestion to integrate brand equity into place branding scholarship and practice, so this study aims to understand how DMO managers are using the construct, if at all. We conducted semi-structured interviews with 12 managers in a Southern U.S. state, and our results suggest that managers do n...

In this chapter some alternatives are discussed to take advantage of parallel computers in dynamic multi-objective optimization problems (DMO) using evolutionary algorithms. In DMO problems, the objective functions, the constraints, and hence, also the solutions, can change over time and usually demand to be solved online. Thus, high performance computing approaches, such as parallel processing...

The Das-Mathur-Okubo (DMO) sum rule for the polarizability of charged pions is evaluated for the Nambu-Jona-Lasinio model Lagrangian in both its minimal and extended forms. A comparison is made with the results obtained using the same sum rule from chiral perturbation theory (χPT), approximate QCD sum rule calculations, explicit calculations on the lattice by Wilcox, and using the semi-empirica...

This paper presents an optimal scheduling model for a microgrid participating in the electricity distribution market in interaction with the Distribution Market Operator (DMO). The DMO is a concept proposed here, which administers the established electricity market in the distribution level, i.e., similar to the role of Independent System Operator (ISO) in the wholesale electricity market, sets...