deep brain stimulation (dbs) is a neurosurgical procedure that enables brain structures to be stimulated electrically by a pacemaker implanted under the skin. in the 1980s, over a decade after its first use in pain, implantable dbs of the thalamus was performed to suppress tremor in parkinson’s disease (pd) refractory to drug treatments. primate-based research soon afterwards identified the sub...

Self-assembling DNA nanostructures are an efficient means of executing parallel molecular computations. However, previous experimental demonstrations of computations by DNA tile self-assembly only allowed for one set of distinct input to be processed at a time. Here, we report the multibit, parallel computation of pairwise exclusive-or (XOR) using DNA "string tile" self-assembly. A set of DNA t...

supramolecule self assembly polyamidoamine (pamam) dendrimer refers to the chemical systems made up of a discrete number of assembled molecular subunits or components. these strategies involve the covalent assembly of hierarchical components reactive monomers, branch cells or dendrons around atomic or molecular cores according to divergent/convergent dendritic branching principles, systematic f...

DNA tiles provide a promising technique for assembling structures with nanoscale resolution through self-assembly by basic interactions rather than top-down assembly of individual structures. Tile systems can be programmed to grow based on logical rules, allowing for a small number of tile types to assemble large, complex assemblies that can retain nanoscale resolution. Such algorithmic systems...

Abstract Herein, a strategy is proposed to simultaneously deliver the small-molecule drug metformin and siRNA with self-assembled DNA nanostructures. The biomedical application of nanostructures highly promising but still in its infancy. as delivery vehicles are conventionally synthesized magnesium-containing buffer. We propose using an anticancer assemble them for synergistic therapy. cargo in...

Nature uses non-covalent interactions to achieve structural dynamic reconfiguration of biopolymers. Taking advantage the programmability DNA/DNA we report here rational design orthogonal DNA-based addressable tiles that self-assemble into polymer-like structures can be reconfigured by external inputs. The different share same sticky ends responsible for self-assembly but are rationally designed...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

The Chapter describes the use of DNA for molecular-scale self-assembly. DNA-nanostructures provide a versatile toolbox with which to organize nanoscale materials. We begin with a discussion of DNA-nanostructures, starting with the self-assembly of various building-blocks known as DNA tiles. We describe how these can be made to self-assemble into two and threedimensional lattices. We discuss var...

In order to self-assemble desired DNA nanostructure, it is necessary to suppress assembly errors caused by fluctuations of temperature and concentration. We propose a microfluidic device to directly control such environmental parameters of DNA self-assembly. In this paper, some experimental results concerned with key processes of self-assembly in the device, such as immobilizing DNA strands in ...

The polymer modification of short nucleotide sequences has been achieved for future use as self-assembled biologically active structures with sizes in the nanometre range. Co-assembly of the resulting DNA-based amphiphilic block copolymers with native proteins demonstrates the self-assembly of biological-like vesicular structures.