نتایج جستجو برای: dna integrity
تعداد نتایج: 570806 فیلتر نتایج به سال:
Within the EU-SPIDIA project (www.spidia.eu), the quality parameters of blood genomic DNA were defined [SPIDIA-DNA: an External Quality Assessment for the pre-analytical phase of blood samples used for DNA-based analyses - [1]; Influence of pre-analytical procedures on genomic DNA integrity in blood samples: the SPIDIA experience - [2]; Combining qualitative and quantitative imaging evaluation ...
In this article, we present an overview on the role of marine pollutants in impairment of DNA integrity in marine gastropods exposed to xenobiotics released from various sources into the coastal ecosystem. We provide an insight into the impact of various types of genotoxic compounds on the physiologic status of marine organisms, with specific focus on DNA integrity. DNA damage in marine gastrop...
Introduction: Cryopreservation of semen is routinely used in a variety of circumstances including before assisted reproduction treatments, pre- radiation or chemotherapy treatment and etc. The aim of this study was to compare the effect of Butylated hydroxytoluene (BHT) and Glutathione supplemented cryopreservation medium on sperm parameters and amount of DNA fragmentation during the freeze-tha...
background: the initial step in the diagnostic investigation of male infertility has been traditionally based on the conventional seminal profile. however, there are significant limitations regarding its ability to determine the underlying mechanisms that cause the disorder. sperm dna fragmentation has emerged as a potential causative factor of reproductive failure and its assessment has been s...
Exposure to non-cytotoxic concentrations of E551 and E172 causes similar changes in the expression levels genes related regulation oxidative stress DNA integrity Drosophila intestines human differentiated Caco-2 cells.
The interplay between dietary habits and individual genetic make-up is assumed to influence risk of cancer, via modulation of DNA integrity. Our aim was to characterize internal and external factors that underlie inter-individual variability in DNA damage and repair and to identify dietary habits beneficial for maintaining DNA integrity. Habitual diet was estimated in 340 healthy individuals us...
BACKGROUND Assessment of DNA integrity and quantity remains a bottleneck for high-throughput molecular genotyping technologies, including next-generation sequencing. In particular, DNA extracted from paraffin-embedded tissues, a major potential source of tumor DNA, varies widely in quality, leading to unpredictable sequencing data. We describe a picoliter droplet-based digital PCR method that e...
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