Structural DNA nanotechnology is a rapidly emerging field that has demonstrated great potential for applications such as single molecule sensing, drug delivery, and templating molecular components. As the applications of DNA nanotechnology expand, a consideration of their mechanical behavior is becoming essential to understand how these structures will respond to physical interactions. This rev...

With the development of deoxyribonucleic acid (DNA) nanotechnology, various DNA nanostructures and devices have been constructed, which exhibit potential applications in material science biomedicine. Taking advantage programmability biocompatibility DNA, novel building block to chemically functionalize with hydrophobic organic molecules has attracted more attention. Driving by amphiphilicity, D...

Nucleic acids, DNA and RNA, not only allow transfer and replication of densely coded genetic information, but also act as danger signals triggering innate immune response. Recent progress in the design and construction of nano-sized structures using DNA has opened a new field of nanotechnology. The unique properties of nano-sized DNA constructs can be exploited to develop programmable materials...

Structural DNA nanotechnology utilizes DNA molecules as programmable information-coding polymers to create higher order structures at the nanometer scale. An important milestone in structural DNA nanotechnology was the development of scaffolded DNA origami in which a long single-stranded viral genome (scaffold strand) is folded into arbitrary shapes by hundreds of short synthetic oligonucleotid...

We report the usage of DNA hydrogels for enzyme entrapment in an enzymatic biobattery. With the recent advancements in DNA nanotechnology, the incorporation of DNA materials to bioelectrocatalytic electrodes holds great promise to improve the performance of bioelectrocatalysis-based devices.

Abstract From a programming perspective, DNA is stunningly simple: string of bits coding two types interactions. The specific chemical form given to us by evolution imposes significant constraints on what possible with nanotechnology. In this paper, I propose three designs for new digital DNA-like polymers that retain the essential information-bearing properties while enabling functions not ach...

Metal ion interactions with DNA have far-reaching implications in biochemistry and DNA nanotechnology. Ag(+) is uniquely interesting because it binds exclusively to the bases rather than the backbone of DNA, without the toxicity of Hg(2+). In contrast to prior studies of Ag(+) incorporation into double-stranded DNA, we remove the constraints of Watson-Crick pairing by focusing on homo-base DNA ...

The emergence of hybrid DNA–protein nanostructures in recent years has expanded the application DNA nanotechnology. Previous studies reported integration proteins into by sequence-dependent interactions or chemical modifications DNA, which limit design flexibility nanostructures. Here we report construction sequence-independent geometry-based using self-assembly single-stranded (ss) and histone...

DNA strand exchange is catalyzed by molecular crowding and hydrophobic interactions in concentrated aqueous solutions of polyethylene glycol, a discovery of relevance for understanding the function of recombination enzymes and with potential applications to DNA nanotechnology.