Amentoflavone has been identified as a JAK2 inhibitor by structure-based virtual screening of a natural product library. In silico optimization using the DOLPHIN model yielded analogues with enhanced potency against JAK2 activity and HCV activity in cellulo. Molecular modeling and kinetic experiments suggested that the analogues may function as Type II inhibitors of JAK2.

We show that dolphin whistle types tend to be used in specific behavioral contexts, which is consistent with the hypothesis that dolphin whistle have some sort of “meaning”. Besides, in some cases, it can be shown that the behavioral context in which a whistle tends to occur or not occur is shared by different individuals, which is consistent with the hypothesis that dolphins are communicating ...

Mobile phone based potable water quality assessment device is developed to analyze and study water pollution level at Indus river. Indus river is habitat of endangered Indus river dolphin and water pollution is one of major causes of survivability threats for this specie. We tested device performance at the six locations of Lahore canal. pH of canal water deviates from the normal range of the i...

Simplified Dolphin Echolocation (SDE) optimization is an improved version of the Dolphin Echolocation optimization. The dolphin echolocation (DE) is a recently proposed metaheuristic algorithm, which was imitated dolphin’s hunting process. The global or near global optimum solution modeled as dolphin’s bait, dolphins send sound in different directions to discover the best bait among their searc...

The aim of this study was an analysis of the time required to swim to a victim and tow them back to shore, while perfoming the flutter-kick and the dolphin-kick using fins. It has been hypothesized that using fins while using the dolphin-kick when swimming leads to reduced rescue time. Sixteen lifeguards took part in the study. The main tasks performed by them, were to approach and tow (double ...

Small-scale artisanal fisheries can have a significant negative impact in cetacean populations. Cetacean bycatch has been documented in the pole-and-line tuna fishery in the Azores with common dolphins being the species more frequently taken. Based on data collected by observers on ∼50% of vessels operating from 1998 to 2012, we investigate the influence of various environmental and fisheries-r...

Cetacean (dolphin, whale, and porpoise) brains are among the least studied mammalian brains because of the formidable challenge of collecting and histologically preparing such relatively rare and large specimens. Magnetic resonance imaging offers a means of observing the internal structure of the brain when traditional histological procedures are not practical. Furthermore, internal structures ...

Globally distributed, the bottlenose dolphin (Tursiops truncatus) is found in a range of offshore and coastal habitats. Using 15 microsatellite loci and mtDNA control region sequences, we investigated patterns of genetic differentiation among putative populations along the eastern US shoreline (the Indian River Lagoon, Florida, and Charleston Harbor, South Carolina) (microsatellite analyses: n ...

Niche exploitation by an organism cumulatively results from its existing adaptations and phylogenetic history. The biological sonar of dolphins is an adaptation for object (e.g. prey or obstacle) detection and classification in visually limited environments. Current biomimetic modeling of echo discrimination by dolphins emphasizes the mechanical and neurological filtering of the peripheral audi...

This is the first study to report on concentrations of perfluorinated organochemicals (FOCs) in marine mammals stranded along the southern North Sea coast in relation to stable nitrogen and carbon isotope ratios (delta15N and delta13C). The presence of FOCs in top predators such as marine mammals would indicate a potential biomagnification of these compounds and their widespread occurrence. Liv...