effective symptomatic relief in patients with dysmotility-like functional dyspepsia, and is widely used in the treatment of gastritis. Gastric motility may be regulated by multiple neural systems. Studies on the mechanisms involving the neuronal systems suggest the involvement of cholinergic and noradrenergic systems. Additionally, various studies have suggested the existence of dopamine neuron...

      The first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using PEG 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. The second objective was to apply the modified solvent method for preparation of sustained re...

Breastfeeding is an economic and valuable method to protect infant health during the life and provides unique biological and emotional effect for mothers and infants.  Objectives: This study was designed to compare effect of fennel on maternal serum prolactin level and neonatal weight gain to effect of domperidone and placebo on these variables.  Research method and materials: In this study 1...

Domperidone is a specific dopamine antagonist that does not exert central anti dopaminergic activity in vivo, probably because it does not readily cross the blood brain barrier (Costall et al., 1979; Laduron and Leysen, 1979). In this study, domperidone has been compared with haloperidol in three different experimental situations where dopamine and/ or apomorphine are known to act: in vivo dopa...

Horses with pituitary pars intermedia dysfunction (PPID) react to domperidone administration with an exaggerated increase in endogenous adrenocorticotropins (ACTH) concentrations. Specifically, a dose of 2.5 mg/kg domperidone orally resulted in an endogenous ACTH concentration in PPID horses that was 2.9 0.68 times baseline values at 4 h post-administration. Endogenous ACTH concentrations in ho...

Dopamine receptors type 2 (D2)-like receptor blockers cause an increase in the norepinephrine response to intense physical exercise. However, during intense physical exercise, D2-like antagonists also cause an increase in the epinephrine response, which itself might cause an increase in plasma norepinephrine through the activation of beta2 presynaptic receptors. Therefore, we evaluated the effe...

Agonists of dopamine receptors can lower blood pressure by vasodilation through action on dopamine1 receptors, inhibition of sympathetic nerve activity by action on dopamine2 receptors, or actions in the central nervous system. Fenoldopam, a selective dopamine1 agonist, piribedil, a selective dopamine2 agonist, and dipropyl dopamine, a mixed dopamine1 and dopamine2 agonist, were injected intrav...

Serum prolactin (PRL) levels in basal conditions (two samples) and 30, 60, 90, 120, 150 e 180 minutes after oral administration of baclofen (20 mg) were evaluated in 6 healthy subjects and in 10 patients with prolactinoma. The effect of baclofen (20 mg by mouth) on the PRL secretion cimetidine (400 mg i.v.) or domperidone (20 mg i.v.) induced were evaluated in 9 healthy women by administration ...

A validated reverse phase high performance liquid chromatography method has been developed for the simultaneous determination of Dexrabeprazole and Domperidone in combined dosage form. Chromatography was carried out on a C-18 column (4.6 mm × 250 mm, 5 μm) using Acetonitrile: 0.025 M potassium dihydrogen orthophosphate buffer (pH adjusted to 5.1 with triethylamine) in the ratio of 30:70 (v/v) a...

A simple, specific and sensitive reverse phase high performance liquid chromatographic method was developed and validated for simultaneous determination of esomeprazole and domperidone from pharmaceutical dosage forms. The method uses ODS C18 column and isocratic elution. The mobile phase composed of methanol: phosphate buffer (pH 4.0) in the ratio of 65:35 v/v was used at a flow rate of 1.0 ml...