نتایج جستجو برای: donepezil hydrochloride
تعداد نتایج: 45696 فیلتر نتایج به سال:
Design and Evaluation of Chitosan Nanoparticles as Novel Drug Carriers for the Delivery of Donepezil
The present study deals with the formulation and evaluation of chitosan nanoparticles containing donepezil hydrochloride for the targeted delivery to the brain. Nanoparticles were prepared by ionic gelation method using sodium tripolyphos-phate (TPP) as a cross linking agent followed by sonication. Nanoparticles were obtained in the average size ranging from 116.8 to 227.5 nm. Particle m...
OBJECTIVE To compare longitudinal changes in the hippocampal structure in subjects with very mild dementia of the Alzheimer type (DAT) treated with donepezil hydrochloride, untreated subjects with very mild DAT, and controls without dementia. DESIGN MPRAGE sequences were collected approximately 2 years apart on two 1.5-T magnetic resonance imaging systems, yielding 2 cohorts. Large-deformatio...
OBJECTIVE To examine the feasibility and test-retest reliability of encoding-task functional magnetic resonance imaging (fMRI) in mild Alzheimer disease (AD). DESIGN Randomized, double-blind, placebo-controlled study. SETTING Memory clinical trials unit. PARTICIPANTS We studied 12 patients with mild AD (mean [SEM] Mini-Mental State Examination score, 24.0 [0.7]; mean Clinical Dementia Rat...
AIM The aim of this study was to characterize the pharmacokinetics and pharmacodynamics of donepezil HCl, a new, chemically distinct and specific acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer's disease, following multiple-dose administration. METHODS This was a double-blind, randomized, placebo-controlled, multiple-dose study in healthy male volunteers (n=27). Three dos...
AIMS The primary objective of this study was to characterize the pharmacokinetics and pharmacodynamics of single daily doses of donepezil (5 and 10 mg) each evening for 28 consecutive days. A secondary objective was to measure the plasma protein binding of donepezil at steady state. METHODS This was a double-blind, randomized, multiple-dose study in healthy male (n=13) and female (n=3) volunt...
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