A 71-year-old asymptomatic female with a history of breast cancer status after right total mastectomy had interval development of several new nodules in the left breast in a 1-year time span. Stereotactic biopsy was performed, which revealed multifocal Rosai Dorfman disease in the left breast. The patient was referred to hematology, and computed tomography of the chest/abdomen/pelvis did not de...

Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease is a rare disorder characterized by proliferation of distinctive histiocytes within lymph node sinuses and lymphatics, sometimes involving extranodal sites. However, clinical suspicion is difficult and there is also a lack of useful diagnostic markers for this disorder prior to histological confirmation. High ...

Any patient with bilateral lymphadenopathy especially in Indian subcontinent is regarded as suffering from tuberculosis unless proved otherwise. This sometimes leads to unwarranted delay in correct diagnosis and management if there is ignorance regarding other rarer etiologies. Rosai-Dorfman Disease (RDD) may present in the same manner and should always be kept on the back of the mind to help a...

BACKGROUND Rosai-Dorfman disease is a non-Langerhans cell histiocytosis that recently has been treated successfully with imatinib mesylate in a patient with a systemic variant of the disease. OBSERVATIONS We describe a 69-year-old man with cutaneous Rosai-Dorfman disease manifesting as progressive, deeply infiltrated skin lesions. Histopathologic examination of the lesions demonstrated dense ...

Background. Rosai-Dorfman disease (RDD) is a benign histiocytic proliferative disorder of unknown etiology. This rare condition commonly causes massive cervical lymphadenopathy. Intracranial RDD without any nodal involvement is extremely rare. Case Report. A young Bangladeshi male complained of bilateral complete blindness with left sided deafness for about three years. There was no lymphadenop...