objective: elevated amino acid homocysteine (hcy) levels and insufficient physical activity are the risk factors in alzheimer disease (ad) development. the effect of intermittent aerobic training on memory retention test and thiobarbituric acid reactive substances (tbars) and superoxide dismutase (sod) levels in the dorsal hippocampus of rats which were stimulated with hcy is investigated. meth...

these experiments examined the effects of pre-test intra dorsal hippocampus (intra-ca1) administration of gabaa receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. male nmri mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received ip injections of either saline (10 ml/kg...

Although there is general consensus that the hippocampus is not critically involved in the acquisition of fear conditioned to an explicit conditioned stimulus (CS), the extent to which the hippocampus participates in contextual fear conditioning remains unclear. To further characterize the potential role of the hippocampus in contextual fear conditioning, the present experiments examined the ef...

Feature outcome of hippocampus and extra-hippocampal cortices was evaluated in melatonin treated lithium-pilocarpine epileptic rats during early and chronic phases of temporal lobe epilepsy (TLE). After status epilepticus (SE) induction, 5 and 20 mg/kg melatonin were administered for 14 days or 60 days. All animals were killed 60 days post SE induction and the histological features of the rosrt...

We showed that when CA3 pyramidal neurons in the caudal 80% of the dorsal hippocampus had almost disappeared completely, the efferent pathway of CA3 was rarely detectable. We used the mouse pilocarpine model of temporal lobe epilepsy (TLE), and injected iontophoretically the anterograde tracer phaseolus vulgaris leucoagglutinin (PHA-L) into gliotic CA3, medial septum and the nucleus of diagonal...

Regier PS, Amemiya S, Redish AD. Hippocampus and subregions of the dorsal striatum respond differently to a behavioral strategy change on a spatial navigation task. J Neurophysiol 114: 1399–1416, 2015. First published June 18, 2015; doi:10.1152/jn.00189.2015.— Goal-directed and habit-based behaviors are driven by multiple but dissociable decision making systems involving several different brain...

Morphological and electrophysiological evidence has been accumulated in recent years to indicate that a functional gradient exists along the septo-temporal axis of the hippocampus such that spatial memory is associated primarily with the dorsal (septal) sector while the functions of the ventral sector are not yet clearly defined. Also, the ventral hippocampus (VH) is reported to express a much ...

We examined reflected light as a measure of neural activity from a 2 mm2 area of dorsal hippocampus and surrounding neocortex in nine freely behaving cats during sleep and waking states. Light reflectance at 660 or 700 nm was measured by a coherent fiber optic probe attached to a charge-coupled device video camera that allowed acquisition of images from subcortical structures. In the dorsal hip...

Our previous experiments demonstrated that social isolation (SI) caused AD-like tau hyperphosphorylation and spatial memory deficits in middle-aged rats. However, the underlying mechanisms of SI-induced spatial memory deficits remains elusive. Middle-aged rats (10 months) were group or isolation reared for 8 weeks. Following the initial four-week period of rearing, citalopram (10 mg/kg i.p.) w...