نتایج جستجو برای: dosage adjustment
تعداد نتایج: 174828 فیلتر نتایج به سال:
introduction: drug utilization evaluation (due) studies are designed to assess drug usage appropriateness. dues have traditionally focused on drugs with high price tags, complicated dosage schedules, narrow therapeutic indices and regular side effects. the primary goal of the present study is to evaluate imipenem usage in bone marrow transplantation (bmt) wards. methods: the study was a prospec...
After a single 500-mg intravenous dose of metronidazole, plasma and dialysate levels were measured over a 7.5-h period in five patients undergoing peritoneal dialysis for terminal renal failure. Approximately 10% of this dose was removed by dialysis during that period, and therapeutic levels were maintained in plasma. No routine adjustment in the dosage of metronidazole appears necessary in pat...
The end product of drug development is the use of the drug in clinical therapy. When a drug has a narrow margin of therapeutic safety, we must steer its dosage between one that is too low, and likely to be ineffective on the one hand, or too high, and likely to be toxic, on the other. We must carefully plan and individualize the dosage for each patient, to achieve some desired target goal such ...
BACKGROUND AND AIM Reduced renal function requires dose adjustment for certain drugs to avoid toxicity. The aim of this study was to determine whether appropriate dosage adjustments were made for drugs that are nephrotoxic, excreted, or metabolized (TEM medications) by the kidney in patients with renal impairment. METHODOLOGY A cross-sectional study of a group of hospitalized patients was car...
Drug dosage adjustment for patients with acute or chronic kidney disease is an accepted standard of practice. The challenge is how to accurately estimate a patient's kidney function in both acute and chronic kidney disease and determine the influence of renal replacement therapies on drug disposition. Kidney Disease: Improving Global Outcomes (KDIGO) held a conference to investigate these issue...
OBJECTIVE Patients with mechanical heart valves require lifelong oral anticoagulant treatment which entails frequent blood sampling and dosage adjustment. The purpose of this study was to investigate the feasibility of letting heart valve operated patients manage blood specimen analysis and dosage adjustment themselves. METHODS A total of 21 patients were enrolled in the study and followed fo...
BACKGROUND Dose adjustment for certain drugs is required in patients with reduced renal function to avoid toxicity as many drugs are eliminated by the kidneys. The aim of this study was to assess whether appropriate dosage adjustments were made in hospitalized patients with renal impairment. METHODS A prospective cross-sectional study was carried out in the internal medicine wards of Tikur An...
BACKGROUND AND PURPOSE This study is to investigate the actual using patterns and clinical effects of topiramate in patients with neurosurgical disease as antiepileptic drugs (AEDs) in 94 korean multicenters. METHODS A total of 7,152 patients who had taken topiramate for at least 3 months between August 2008 and February 2009 were eligible to participate in this study. We evaluated demographi...
BACKGROUND Untreated maternal hypothyroidism can have adverse effects on both the mother and fetus, but it can potentially be prevented by adequate levothyroxine replacement. This study was conducted to determine what percentage of hypothyroid pregnant women who were taking levothyroxine needed to adjust their medication dosage, and when and how much it should be increased. METHODS In this lo...
BACKGROUND The dosing of opioid receptor agonist medications adequately and on an individual basis is crucial in the pharmacotherapy of opioid dependence. Clinical tools that are able to measure dose appropriateness are sorely needed. The recently developed and validated Opiate Dosage Adequacy Scale (ODAS) comprehensively evaluates the main outcomes relevant for methadone dose optimization, nam...
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