AIMS Several studies reported treatment benefits of tolvaptan in patients with congestive heart failure (CHF). However, the optimal dosage remains unclear. We aimed to compare different dosage of tolvaptan to determine the optimal dosage in terms of the efficacy and safety. METHODS We searched MEDLINE, PubMed, EMBASE, Cochrane CENTRAL and ClinicalTrials.gov through Aug 31, 2016. Randomized co...

Some empirical studies and recent developments in pharmacokinetic theory suggest that statistical random-effects linear models are valuable tools that allow describing simultaneously patient populations as a whole and patients as individuals. This remarkable characteristic indicates that these models may be useful in the development of personalized medicine, which aims at finding treatment regi...

This paper summarizes the findings from two recent studies involving the physiological effects of atropine (0 to 4 mg, im) on soldiers performing physical exercise in hot-dry environments. Study I determined the threshold of physiological effects and the gradation of these effects with increasing dosage of atropine. Study II examined the effects of exercise-heat acclimation on the reduced physi...

abstract in low-input cropping systems, the natural roles of microorganisms in maintaining soil fertility may be more important than conventional system. in order to investigate the effects of plant growth promoting fungi on improvement of growth and development in soybean (cv: jk) an experiment was conducted at the research farm of sari agricultural sciences and natural resources university du...