Radiotherapy is an important and one of the most effective curative and palliative modality of cancer treatment. Symptomatic bone metastases (M1OSS) represent an important problem in oncology. External beam radiotherapy (EBRT) is effective in palliating pain from bone metastases, being rapid treatment without major toxicities. There are many fractionation schemas and a certain percent of patien...

PURPOSE To investigate whether current fractionation and brachytherapy protraction schemes for the treatment of prostatic cancer with radiation are optimal, or could be improved. METHODS AND MATERIALS We analyzed two mature data sets on radiotherapeutic tumor control for prostate cancer, one using EBRT and the other permanent seed implants, to extract the sensitivity to changes in fractionati...

Arginine-glycine-aspartic acid (RGD) peptides preferentially bind to alphavbeta3 integrin, an integrin expressed on newly formed endothelial cells and on various tumor cells. When labeled with beta-emitting radionuclides, these peptides can be used for peptide-receptor radionuclide therapy of malignant tumors. These studies aimed to investigate whether tumor targeting and tumor therapy could be...

Traditionally, as a standard dose fractionation schedule, adjuvant radiotherapy for breast cancer has been performed using prescribed doses of 46–50 Gy divided into daily fractions 1.8–2 Gy. Overall, treatment took 5 weeks. In the 1990s, schedules higher (2.5–3 Gy), smaller number (hypofractionation), and reduced overall started in context clinical trials. First results revealed an equivalent c...

BACKGROUND An advantage of the Intensity Modulated Radiotherapy (IMRT) technique is the feasibility to deliver different therapeutic dose levels to PTVs in a single treatment session using the Simultaneous Integrated Boost (SIB) technique. The paper aims to describe an automated tool to calculate the dose to be delivered with the SIB-IMRT technique in different anatomical regions that have the ...

BACKGROUND The ongoing yellow fever epidemic in Angola strains the global vaccine supply, prompting WHO to adopt dose sparing for its vaccination campaign in Kinshasa, Democratic Republic of the Congo, in July-August, 2016. Although a 5-fold fractional-dose vaccine is similar to standard-dose vaccine in safety and immunogenicity, efficacy is untested. There is an urgent need to ensure the robus...

While radical cystectomy remains the primary treatment of choice for bladder cancer, increased evidence supports use bladder-preservation strategies based on adjuvant radiotherapy. This highlights need a better understanding cancer radiosensitivity to different types deliveries. The purpose this study is analyze effect time, dose and fractionation number sizes grown three-dimensional (3D) spher...