نتایج جستجو برای: dose profile
تعداد نتایج: 520949 فیلتر نتایج به سال:
The aim of the procedure is to determine the optimal sampling times for the assessment of AUC after administration of a drug, either as a single dose or during a regular dosing schedule. For a single dose, AUC is defined as the total area under the plasma concentration time profile from time zero to infinity; for a regular dosing interval at steady state, AUC is defined as the area under the pl...
Background: Dose calculation algorithms play a very important role in predicting the explicit dose distribution. We evaluated the percent depth dose (PDD), lateral depth dose profile, and surface dose volume histogram in inhomogeneous media using calculation algorithms and inhomogeneity correction methods. Materials and Methods: The homogeneous and inhomogeneous virtual slab phantoms used in th...
introduction: the purpose of this work was to study the ability of mri normoxic polymer gel dosimetry for evaluating the dose distribution in hdr brachytherapy of esophagial cancer at imam reza brachytherapy center (mashhad, iran). materials and methods: initially, 2liters of normoxic gel (magic) was fabricated and then poured into 12 calibration test tubes and placed in a perspex walled phanto...
This study to evaluate the effect of hormone replacement therapy ( HRT ) and low-dose combinated oral pill on skin thickness , lipid profile and blood chemistry on menopausal woman.This study was carried out in one year randomized prospective study. 36 women were divided into 18 women receiving HRT and the other 18 receiving low-dose oral pill. The result of this study showed an increase in ski...
objective(s) as there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (vpa), this study was conducted to investigate the relationship between patient demographic characteristics, vpa dosage and the drug clearance in adult iranian patients. materials and methods patients (n= 47) were either on monotherapy with vpa or were under co...
PURPOSE The (6-maleimidocaproyl)hydrazone derivative of doxorubicin (DOXO-EMCH) is an albumin-binding prodrug of doxorubicin with acid-sensitive properties that shows superior antitumor efficacy in murine tumor models and a favorable toxicity profile in mice, rats, and dogs compared with doxorubicin. The purpose of the phase I study was to characterize the toxicity profile of DOXO-EMCH, establi...
OBJECTIVE Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy was developed to provide a cortisol exposure-time profile that closely resembles the physiological cortisol profile. This study aimed to characterize single-dose pharmacokinetics (PK) of DR-HC 5-20mg and assess intrasubject variability. METHODS Thirty-one healthy Japanese or non-Hispanic Caucasian volunteers age...
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