Introduction: The GABAergic system of the brain plays a key role in morphine tolerance and sensitization. As isoniazid is a modulator of the GABAergic system, the present study aims to understand whether isoniazid can influence the induction of tolerance and sensitization to the rewarding effects of morphine.  Methods: The rewarding effects of morphine and isoniazid were assessed using a Condi...

abstract water deficit is a major problem for the successful production of agricultural products in iran. this research was conducted to evaluate drought tolerance indices and identifying drought tolerant cultivars of canola. twenty eight canola cultivars were sassed implementing complete block designs experiments in normal and drought stress conditions at isfahan university of technology resea...

The effect of NMDA (N-methyl-D-aspartate) receptor antagonists on tolerance to morphine antinociception was investigated in mice. Daily subcutaneous administration of 50 mg/kg of morphine hydrochloride for three days induced tolerance to different (3,6 and 9 mg/kg) test doses of morphine. The tolerance obtained was decreased by pretreatment of animals with single or repeated doses of compe...

the effect of nmda (n-methyl-d-aspartate) receptor antagonists on tolerance to morphine antinociception was investigated in mice. daily subcutaneous administration of 50 mg/kg of morphine hydrochloride for three days induced tolerance to different (3,6 and 9 mg/kg) test doses of morphine. the tolerance obtained was decreased by pretreatment of animals with single or repeated doses of competitiv...

in the present study, the effects of caerulein and cck receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for ant...

Development of a green belt with suitable plant species around the source of emission can mitigate the atmospheric contamination. Selection of such plant species are required to combat air pollution based on their tolerance level. Present study was undertaken to evaluate the tolerance level of higher plants in East of Esfahan city, Iran, during 2011 in terms of assessing Air Pollution Tolerance...

abstracta pot study was conducted in order to evaluate the effect of plant growth promoting rhizobia (pgpr) on canola growth and ionic composition under salt stress conditions, was conducted as factorial in randomized complete block design with three replications. salinity in four levels of 0, 3, 6 &9 ds/m were evaluated with mixture of salts nacl & mgcl2. canola seeds were inoculated with sele...

Background: Previous studies have indicated that administration of saffron extract could induced reward and reduces morphine reward as investigated by place preference and behavioral sensitization in male and female mice. In the present study, the effects of water extract of Crocus sativus on the acquisition and expression of tolerance to morphine-induced hyperalgesia in female N-MRI mice (20-...