BACKGROUND Dietary phytosterols, plant sterols structurally similar to cholesterol, reduce intestinal cholesterol absorption and have many other potentially beneficial biological effects in humans. Due to limited information on phytosterol levels in foods, however, it is difficult to quantify habitual dietary phytosterol intake (DPI). Therefore, we sought to identify a plasma biomarker of DPI. ...

BACKGROUND Swine influenza (SI) is an acute respiratory disease caused by swine influenza virus (SIV). Swine influenza is generally characterized by acute onset of fever and respiratory symptoms. The most frequent complications of influenza are secondary bacterial pneumonia. The objective of this work was to study the acute phase proteins (APP) responses after coinfection of piglets with H1N1 s...

The present study analyzed the effect of intra-accumbens administration of the stereoisomers of sulpiride upon (3,4-dihydroxyphenylimino)-2-imidazoline (DPI)-induced changes in oral behaviours and electromyographic patterns of jaw muscles. In line with earlier findings, DPI (5 micrograms) administered into the nucleus accumbens increased chewing and tremor. l-Sulpiride (2-50 ng) had no effect o...

Synopsis Double photoionization (DPI) of lithium atoms in a magneto-optical trap by 85 eV and 91 eV photons from the Hamburg Free Electron Laser (FLASH) is investigated using cold target recoil ion momentum spectroscopy. For ejection of a 1s and the optically excited 2p electron we demonstrate that the DPI cross section significantly depends on the alignment of the 2p valence orbital. Thus, the...

Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen described as having a negative impact on adult neurogenesis. The present study investigated the effect of high-dose application Theiler’s encephalomyelitis virus (TMEV)-induced hippocampal damage. Two weeks after TMEV infection, 42% untreated TMEV-infected mice were affec...

Aim To compare the treatment planning decisions made by undergraduate and postgraduate dental students before after training on use of Dental Practicality Index (DPI). Methodology One hundred eight were randomly assigned to test (DPI) or control groups. The baseline knowledge was assessed in first session; both groups shown 15 clinical scenarios asked assign one four plan options (no treatment,...

BACKGROUND To assess the long-term pediatric safety of 2 doses of mometasone furoate administered via a dry powder inhaler (MF-DPI) for mild-to-moderate persistent asthma and compare them with that of beclomethasone dipropionate administered via a metered dose inhaler (BDP-MDI) in the treatment of persistent asthma. Both MF-DPI doses tested are twice the approved pediatric dosage of 100 microg ...

BACKGROUND Handheld inhalers are used to deliver treatment for COPD. Incorrect usage leads to suboptimal disease control. Complex treatment regimens and use of multiple inhalers may reduce patient compliance. The Anoro Ellipta™ dry powder inhaler (DPI) simultaneously delivers umeclidinium bromide (UMEC) and vilanterol (VI) without coformulation being required. AIM To assess the correct usage ...

STUDY OBJECTIVES To investigate the potential for mometasone furoate (MF) to exert systemic effects following administration by dry powder inhaler (DPI) or metered-dose inhaler (MDI). DESIGN Three randomized, evaluator-blind, placebo-controlled, parallel-group, 28-day studies. PATIENTS Adults with mild-to-moderate persistent asthma. INTERVENTIONS Study 1 (12 patients per treatment group; ...