Mutations in the nuclear intermediate fi lament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms. Méjat et al. show that one mechanism involves the disruption of neuromuscular junctions. Muscle fi ber cells contain hundreds of nuclei. In normal fi bers, several nuclei cluster together under the cell membrane at sites of neu...