alpha-1antitrypsin (a1at) deficiency, an inherited disorder, has been shown to be the cause of lung diseases such as emphysema and chronic obstructive pulmonary disease. one of the treatment strategies to provide appropriate and adequate concentrations of a1at in the lungsis the application of nanoparticles (nps) in pulmonary drug delivery. in the current study, biocompatible nanohydrogels were...

ketorolac tromethamine (kt) containing microemulsion-based gels (mbgs) have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant (soybean lecithin; epikuron 200) and oil (isopropyl myristate; ipm) and the effect of formulation variables on the release profile of the drug from mbgs through intact guinea pig skin and various artificial membr...

The aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. The effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. Different miliequivalents of the di and tri-valent cation, Ca2+ and Al3+, were added to tablet form...

The present investigation was aimed at developing a novel colon targeted system of lornoxicam based on the use of a combination of pH dependent system (to prevent the premature release of drug in the upper GIT) and enzymatically degradation system (to ensure the specificity of drug release in the colon). The drug loaded guar gum microspheres prepared by emulsification cross-linking method were ...

the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

it is possible to alter the permeability of ethyl cellulose membrane with certain materials such as surfactants. in this study the effect of surfactant concentration and different hlb values on the release rate of atenolol from ethyl cellulose-coated tablets was evaluated. the results showed that when the concentration of surfactant increased, the rate of drug release also increased. the kineti...

the present study deals with development of a floating in-situ gel of the narrow absorption window drug baclofen. sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which varying concentrations of drug and calcium bicarbonate were added. fourier transform infrared spectroscopy (ftir) and differential scannin...

     The purpose of this work was to develop once daily sustained release (SR) matrix tablets of naproxen, an anti-inflammatory agent. The tablets were prepared by wet granulation method along with hydrophilic matrix materials like Methocel K 15M CR and Methocel K 100M CR. The granules were evaluated for bulk density, angle of repose, compressibility index, total porosity and drug content. The ...

Microspheres formulated from poly (D,L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres ...

in this paper, carbon nanotubes (cnts) were added into chitosan (cs) hydrogels in the form of chitosan modified cnts (cs-cnts) composites to prepare carbon nanotubes hydrogels (cnts-gel). the products, named cs-mwcnts, were characterized by scanning electron microscope (sem) and fourier transform infrared (ftir) spectroscopy. swelling properties and effect of ph on controlled release performanc...