Antituberculosis drug resistance is increasing both in theUnitedKingdomand internationally. 2 It has come to greater public attention with the emergence of extensively drug resistant tuberculosis (box 1) in South Africa, where an outbreak proved rapidly fatal among peoplewith advancedHIV infection. In this articlewe review recent global and UK trends in drug resistant tuberculosis and summarise...

Tuberculosis (TB) is a disease of worldwide public-health concern. The development of resistance to an increasing number of second-line drugs and those used to treat multidrug-resistant (MDR) TB is rapidly becoming an emergency that could hinder the prevention and treatment of TB globally. This study describes the resistance profile of MDR and extensively drug-resistant (XDR) TB with a hospital...

Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant tuberculosis cases, highlight the difficulties in designing universal regimen, and inform future r...

INTRODUCTION Tuberculosis is the most widespread infectious disease in Nepal and poses a serious threat to the health and development of the country. Incidences of drug resistant tuberculosis in Nepal are increasing and this tuberculosis a major threat to successfully controlling tuberculosis. OBJECTIVE The general objective of the study was to assess the risk factors of multi-drug resistant ...

Drug resistant tuberculosis (DR-TB) has been reported since the early days of introduction of antitubercular chemotherapy, but recently multi drug resistant tuberculosis (MDR-TB), has been an area of growing concern, and is posing threat to global efforts of tuberculosis control. Prevalence of MDR-TB, in a community mirrors the functional state and efficacy of tuberculosis control programme and...

Sixty-eight drug-resistant Mycobacterium tuberculosis isolates (44.2% of all resistant cases) were analyzed by IS6110 restriction fragment length polymorphism fingerprinting and spoligotyping to provide a deeper insight into the status of drug-resistant tuberculosis in Hungary. A total of 54.4% of the drug-resistant cases and 75% of the multidrug-resistant cases could be clustered. Analysis of ...

Drug resistance (especially multiple drug resistance) in Mycobacterium tuberculosis makes global concerns in treatment and control of tuberculosis. Rapid diagnosis of drug resistant strains of the bacteria has vital importance in the prognosis of the disease. The aim of this study was to identify the mutations responsible for drug resistance in Mycobacterium tuberculosis strains derived from pa...

Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the s...

mycobacterium tuberculosis, the main cause of tuberculosis (tb), has still remained a global health crisis especially in developing countries. tuberculosis treatment is a laborious and lengthy process with high risk of non compliance, cytotoxicity adverse events and drug resistance in patient. recently, there has been an alarming rise of drug resistant in tb. in this regard, it is an unmet need...

Mycobacterium tuberculosis strains that are resistant to an elevating number of second-line medicines used treat multidrug-resistant becoming a threat public health worldwide. Recent guidelines recommended at least 20 months treatment, but recent regimens toxic, poorly tolerated and insufficiently effective, with cure rates as low 36% failure high 50%. The emergence can be defined isoniazid rif...