INTRODUCTION: Quantification of cerebral blood flow using dynamic contrast enhanced (DCE) MRI [1] has several advantages over conventional dynamic susceptibility contrast (DSC) MRI [2]. Most importantly, DCE-MRI avoids the inherent susceptibility artifacts of DSC-MRI, thus allowing for more reliable measurement of the arterial input function (AIF) and quantification of blood brain barrier leaka...

OBJECTIVE The purpose of this study was to correlate the degree of contrast enhancement on dynamic contrast-enhanced T1-weighted MRI and the relative cerebral blood volume (rCBV) values on T2*-weighted MRI in patients with high-grade brain neoplasms. SUBJECTS AND METHODS Ten patients with biopsy-proven high-grade gliomas underwent dynamic contrast-enhanced MRI using T1-weighted fast spoiled g...

breast cancer continues to be a significant public health problem in the world. early detection is the key for improving breast cancer prognosis. in this way, magnetic resonance imaging (mri) is emerging as a powerful tool for the detection of breast cancer. breast mri presently has two major challenges. first, its specificity is relatively poor, and it detects many false positives (fps). secon...

The passage of a vascular-injected paramagnetic contrast reagent (CR) bolus through a region-of-interest affects tissue (1)H(2)O relaxation and thus MR image intensity. For longitudinal relaxation [R(1) identical with (T(1))(-1)], the CR must have transient molecular interactions with water. Because the CR and water molecules are never uniformly distributed in the histological-scale tissue comp...

Introduction Quantitative susceptibility mapping (QSM) is a new contrast mechanism in magnetic resonance imaging (MRI). The images produced by the QSM enable researchers and clinicians to easily localize specific structures of the brain, such as deep brain nuclei. These nuclei are targets in many clinical applications and therefore their easy localization is a must. In this study, we aimed to i...

Radiological imaging plays an important role in oncological trials to provide imaging biomarkers for disease staging, stratifying patients, defining dose setting, and evaluating the safety and efficacy of new candidate drugs and innovative treatment. This paper reviews the techniques of most commonly used quantitative magnetic resonance imaging (qMRI) biomarkers (dynamic contrast enhanced, dyna...