<b><i>Objective:</i></b> The aim of this study was to investigate the clinicopathological prognostic factors malignant ovarian germ cell tumors (MOGCT) and evaluate survival trends MOGCT by histotype. <b><i>Methods:</i></b> We extracted data on 1,963 cases diagnosed between 2000 2014 from Surveillance, Epidemiology, End Results (SEER) database his...

The evolution of treatment for malignant ovarian germ cell tumors has been one the most successful in history gynecologic oncology, with dysgerminoma as common type tumors. Since introduction platinum-based chemotherapy 1980s, 5-year survival rates early-stage dysgerminomas have close to 100%, and high 98% advanced stages. Despite this remarkable achievement, many questions remain routine treat...

Recent generation of induced pluripotent stem (iPSCs) has made a significant impact on the field of human regenerative medicine. Prior to the clinical application of iPSCs, testing of their safety and usefulness must be carried out using reliable animal models of various diseases. In order to generate iPSCs from common marmoset (CM; Callithrix jacchus), one of the most useful experimental anima...

Ovotesticular DSD is not an uncommon disorder. The presence of Y chromosome confers a high risk of neoplastic transformation in dysgenetic gonads. The neoplastic development in these patients is associated with the presence of Y chromosome and intra abdominal location of the abnormal gonad. We report histogenetic details of a rare occurrence of bilateral gonadoblastomas and left sided dysgermin...

To cite: Vale-Fernandes E, Rodrigues F, Monteiro C, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015212550 DESCRIPTION A dysgerminoma is a very rare and malignant tumour originating from the ovarian primordial germ cells. Germ cell tumours account for 2.6% of all ovarian malignant tumours and about 70% of cases of ovarian cancer in the early decades of ...