Patients 1801 patients ≥ 60 years of age (mean age 71 y, 65% women) who met the Diagnostic and Statistical Manual of Mental Disorders, 4 edition criteria for major depression or dysthymia or both and who were planning to use general medical care from a participating clinic. Exclusion criteria were drinking problems, bipolar disorder or psychosis, severe cognitive impairment, or acute risk of su...

Childhood mood disorders such as major depression, dysthymia, and bipolar disorder have been found to be highly prevalent among children and adolescents. The emotional and behavioral dysfunction associated with these mood disorders can cause impairments across areas of functioning, including academic and social arenas. This article reviews the course, possible causes, assessment, and treatment ...

BACKGROUND Numerous studies have reported a relationship between depression and temporomandibular disorders (TMD), but the conclusions remain undefined. The aim of this article was to examine the temporal relationship between depression and TMD. METHODS In this retrospective matched case-control study, we recruited all samples from a randomsample sub-dataset of one million insured individuals...

Paroxetine is a selective serotonin reuptake inhibitor (SSRI), with antidepressant and anxiolytic activity. In 6- to 24-week well designed trials, oral paroxetine 10 to 50 mg/day was significantly more effective than placebo, at least as effective as tricyclic antidepressants (TCAs) and as effective as other SSRIs and other antidepressants in the treatment of major depressive disorder. Relapse ...

Although psychotherapy and antidepressant medication are efficacious in the treatment of depressive and anxiety disorders, it is not known whether they are equally efficacious for all types of disorders, and whether all types of psychotherapy and antidepressants are equally efficacious for each disorder. We conducted a meta-analysis of studies in which psychotherapy and antidepressant medicatio...

Participants 375 people aged 18–65 years with generalised social phobia of at least 1 year duration (DSM-IV criteria) rated as moderately ill (score of 4 or greater on overall severity item of the Clinical Global Impression Social Phobia scale, severity sub-scale). Participants were recruited from 41 primary care centres in Norway and Sweden and from advertisements in newspapers and other media...

People with mood disorders often have disruptions in their circadian rhythms. Recent molecular genetics has linked circadian clock genes to mood disorders. Our objective was to study two core circadian clock genes, CRY1 and CRY2 as well as TTC1 that interacts with CRY2, in relation to depressive and anxiety disorders. Of these three genes, 48 single-nucleotide polymorphisms (SNPs) whose selecti...