We have recently presented evidence indicating that during biosynthesis of squalene from farnesyl pyrophosphate by rat liver microsomes, 1 hydrogen atom attached to carbon 1 of 1 of the 2 precursor molecules condensing to squalene was exchanged for a hydride ion derived from reduced triphosphopyridine nucleotide (1). This conclusion was drawn from the observations, (a) that during synthesis of ...

We used the cut-sensillum technique to assess the effect of both adult age and egg-to-adult development time on olfactory neuron responses of Z strain moths of the European corn borer, Ostrinia nubilalis. Compounds tested included the pheromone components, (Z)-11-tetradecenyl acetate and (E)-11-tetradecenyl acetate, the behavioral antagonist, (Z)-9-tetradecenyl acetate, and components of the O....

Using oligonucleotide-mediated 'loop-in' mutagenesis strategies in M13, a heat-inducible ubiquitin (Ub) gene was extended by sequences coding for the C-terminal 11 amino acids of Ha-RAS. The resulting gene was transformed into AR13 and production of the Ub-peptide extension was induced by heat treatment. After one-step purification, the fusion protein (Ub-cRAS) was used as a substrate for farne...

In order to develop efficient lures for soybean pod borer Leguminivora glycinivorella (Matsumura) in China, (E,E)-8,10-dodecadienyl acetate (EE-8,10-12:Ac), the main component of the pheromone of L. glycinivorella, and 12 structurally-related compounds were synthesised in good overall yields, regiospecificities, and stereo-selectivities via coupling reactions catalysed by Li₂CuCl₄. The effect o...

I. Two experimental groups, each of thirteen boarding schoolboys, were given either 400 mg a-tocopheryl acetate or placeboes daily in addition to their normal diet during training in swimming and various athletic activities over a period of 6 weeks. Evaluation of the experimental treatments was made from tests of anthropometric status, cardiorespiratory efficiency and motor fitness and performa...

The association of mutant forms of Ras protein with a variety of human cancers has stimulated intense interest in therapies based on inhibiting oncogenic Ras signaling. Attachment of Ras proteins to the plasma membrane is required for effective Ras signaling and is initiated by the enzyme farnesyl protein transferase. We found that in the presence of potent farnesyl protein transferase inhibito...

In the title compound, C(13)H(14)N(2)O(3)S, the methyl 2-(3-formyl-thio-ureido)acetate fragment and the phenyl ring adopt an E configuration. The mol-ecule exhibits an intra-molecular N-H⋯O hydrogen bond, which completes a six-membered ring. The crystal packing is stabilized by inter-molecular N-H⋯S contacts, generating a two-dimensional hydrogen-bonding network.

BACKGROUND In adults, RRR-alpha-tocopheryl acetate (natural vitamin E) has approximately twice the biological activity of all-rac-alpha-tocopherol (synthetic vitamin E). Similar studies have not been done in term infants. OBJECTIVE We evaluated the vitamin E and antioxidant status of term infants fed formulas differing in the amount and form of vitamin E acetate. DESIGN A controlled, blinde...

In the title compound, C(14)H(16)N(2)O(3)S, the phenyl ring and the ethyl 2-(3-formyl-thio-ureido)acetate fragment adopt an E configuration with respect to the C=C bond. An intra-molecular N-H⋯O hydrogen bond generating an S(6) ring motif is observed. In the crystal, mol-ecules are linked by N-H⋯S, C-H⋯S and C-H⋯O hydrogen bonds, forming sheets lying parallel to the ab plane.