The anterior cingulate cortex (ACC) plays an important role in higher brain functions including learning, memory, and persistent pain. Long-term potentiation of excitatory synaptic transmission has been observed in the ACC after digit amputation, which might contribute to plastic changes associated with the phantom pain. Here we report a long-lasting membrane potential depolarization in ACC neu...

The effect of subthreshold depolarization on mechanical threshold was investigated in tetrodotoxin-poisoned mammalian and amphibian skeletal muscle fibers using a two-microelectrode voltage-clamp technique. Mechanical threshold was determined with a 2-ms test pulse. The immediate effect of depolarization was inhibition of the mechanical system. The consequent increase in the test pulse threshol...

1. In firefly larvae, extracellular recordings from the light organ nerve show that a volley of action potentials elicits a glow of an intact animal. 2. Intracellular recordings from the photocytes show that they respond to nerve stimulation with a slow, graded depolarization which precedes light emission. The depolarization begins about 0-5 s after the nerve is stimulated; it peaks about 1 s a...

ADIFFERENCE has been observed in certain instances between the onset of QRS in intracavitary and surface limb leads. Simultaneous tracings demonstrate that when premature ventricular depolarization exists the early rapid growth in magnitude of potential recorded by intracavitary leads may be nearly or totally inapparent in surface leads. Following premature depolarization changes occur in intra...

ADIFFERENCE has been observed in certain instances between the onset of QRS in intracavitary and surface limb leads. Simultaneous tracings demonstrate that when premature ventricular depolarization exists the early rapid growth in magnitude of potential recorded by intracavitary leads may be nearly or totally inapparent in surface leads. Following premature depolarization changes occur in intra...

ADIFFERENCE has been observed in certain instances between the onset of QRS in intracavitary and surface limb leads. Simultaneous tracings demonstrate that when premature ventricular depolarization exists the early rapid growth in magnitude of potential recorded by intracavitary leads may be nearly or totally inapparent in surface leads. Following premature depolarization changes occur in intra...

We previously showed in dissociated cultures of fetal rat spinal cord that disinhibition-induced bursting is based on intrinsic spiking, network recruitment, and a network refractory period after the bursts. A persistent sodium current (I(NaP)) underlies intrinsic spiking, which, by recurrent excitation, generates the bursting activity. Although full blockade of I(NaP) with riluzole disrupts su...

Introduction: A close link between spreading depression (SD) and several neurological diseases such as epilepsy could be demonstrated in many experimental studies. Epilepsy is among the most common brain disorders. Despite a large number of investigations, its mechanisms have not been yet well elucidated. Hippocampus is one of the important structures involved in seizures. The aim of this st...